Inhibition of DNA topoisomerase I by cryptotanshinone from Salvia miltiorrhiza

被引：0
|
作者：
Lee, DS [1 ]
Hong, SD [1 ]
机构：
[1] Kyungpook Natl Univ, Coll Nat Sci, Dept Microbiol, Taegu 702701, South Korea
来源：
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 1998年 / 8卷 / 01期
关键词：
cryptotanshinone; inhibitor of DNA topoisomerase I;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cryptotanshinone induced topoisomerase I-mediated DNA cleavage in vitro as strongly as camptothecin, whereas topoisomerase II-mediated DNA cleavage was not induced by this agent. In DNA relaxation assay using calf thymus DNA topoisomerase I and supercoiled pBR322 DNA, cryptotanshinone inhibited topoisomerase I-mediated DNA relaxation in a dose-dependent manner. In unwinding assay, cryptotanshinone (50 mu M) did not shift the topoisomers of DNA. These results suggest that cryptotanshinone exerted a preferential inhibition of topoisomerase I without intercalating into DNA.
引用
收藏
页码：89 / 91
页数：3
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