Immune Checkpoint Inhibitors-Related Thyroid Dysfunction: Epidemiology, Clinical Presentation, Possible Pathogenesis, and Management

被引：33

作者：

Zhan, Ling ^{[1
]}

Feng, Hong-fang ^{[1
,2
]}

Liu, Han-qing ^{[1
]}

Guo, Lian-tao ^{[1
]}

Chen, Chuang ^{[1
]}

Yao, Xiao-li ^{[1
]}

Sun, Sheng-rong ^{[1
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Breast & Thyroid Surg, Wuhan, Peoples R China

[2] Hubei Polytech Univ, Edong Healthcare Grp, Affiliated Hosp, Dept Breast Surg,Thyroid Surg,Huangshi Cent Hosp, Huangshi, Hubei, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

immune checkpoint inhibitors; immune-related adverse events; thyroid dysfunction; epidemiology; clinical manifestations; pathogenesis; management; TYPE-1; DIABETES-MELLITUS; REGULATORY T-CELLS; ADVERSE EVENTS; COMBINED NIVOLUMAB; SINGLE-ARM; CANCER; IPILIMUMAB; MULTICENTER; BIOMARKERS; SURVIVAL;

D O I：

10.3389/fendo.2021.649863

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immune checkpoint inhibitors (ICIs) are a group of drugs employed in the treatment of various types of malignant tumors and improve the therapeutic effect. ICIs blocks negative co-stimulatory molecules, such as programmed cell death gene-1 (PD-1) and its ligand (PD-L1) and cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), reactivating the recognition and killing effect of the immune system on tumors. However, the reactivation of the immune system can also lead to the death of normal organs, tissues, and cells, eventually leading to immune-related adverse events (IRAEs). IRAEs involve various organs and tissues and also cause thyroid dysfunction. This article reviews the epidemiology, clinical manifestations, possible pathogenesis, and management of ICIs-related thyroid dysfunction.

引用

页数：13

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