Synthesis of 2-(polyhydroxy)alkyl- and 2-(6-adenosinyl)benzisoselenazol-3(2H)-ones

被引：2

作者：

Osajda, M ^{[1
]}

Mlochowski, J ^{[1
]}

机构：

[1] Wroclaw Univ Technol, Inst Organ Chem Biochem & Biotechnol, PL-50370 Wroclaw, Poland

来源：

SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 08期

关键词：

2-(chloroseleno)benzoyl chloride; benzisoselenazol-3(2H)-ones; nucleosides; polyols; selenium compounds;

D O I：

10.1081/SCC-120018689

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for synthesis of benzisoselenazol-3(2H)-ones substituted on the nitrogen atom with (polyhydroxy)alkyl or adenosinyl group is presented. It is based on the tandem acylationselenenylation of primary amino group in aminopolyols or adenosine with 2-(chloroseleno)benzoyl chloride. The process is selective because oxygen nucleophiles (hydroxy groups) remained unreactive in the reaction conditions.

引用

页码：1301 / 1307

页数：7

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