Antitumor Effect of Plasma Treatment on U87 Glioma Xenografts: Preliminary Results

被引：219

作者：

Vandamme, Marc ^{[1
,2
]}

Robert, Eric ^{[1
]}

Pesnel, Sabrina ^{[2
]}

Barbosa, Emerson ^{[1
]}

Dozias, Sebastien ^{[1
]}

Sobilo, Julien ^{[2
]}

Lerondel, Stephanie ^{[2
]}

Le Pape, Alain ^{[2
]}

Pouvesle, Jean-Michel ^{[1
]}

机构：

[1] Univ Orleans, GREMI, CNRS, UMR 6606, F-45067 Orleans 2, France

[2] CNRS, TAAM CIPA, UPS44, F-45071 Orleans 2, France

来源：

PLASMA PROCESSES AND POLYMERS | 2010年 / 7卷 / 3-4期

关键词：

cancer therapy; dielectric barrier discharges (DBD); non-thermal plasmas; plasma medicine; xenograft model antitumor assay; DIELECTRIC BARRIER DISCHARGE; ALTERNATING ELECTRIC-FIELDS; BLOOD-COAGULATION; INDUCED APOPTOSIS; CULTURED-CELLS; STERILIZATION; HYPERTHERMIA; CANCER; REMOVAL; MODELS;

D O I：

10.1002/ppap.200900080

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

This work was conducted to evaluate the potential antitumor effect of an in vivo plasma treatment on a U87-luc glioma tumor. A pulsed DBD with mu s pulses at moderate power was used for treatment. Electrical analyses and spectroscopic measurements were realized to characterize plasma properties. We showed that the plasma treatment was safe for mice. However, the reiterated long time plasma treatment (20 mm, 3 consecutive days) produces a superficial burn. During plasma treatment, we observed an increase of subcutaneous temperature and a cutaneous skin pH reduction. After 5 d of plasma treatment, we observed a dramatical U87 bioluminescence decrease associated with a reduction of tumor volume in U87 glioma-bearing mice.

引用

页码：264 / 273

页数：10

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