RETRACTED: Homoharringtonine-induced apoptosis of MDS cell line MUTZ-1 cells is mediated by the endoplasmic reticulum stress pathway (Retracted article. See vol. 57, pg. 1241, 2016)

被引：20

作者：

Hu Jie

He Donghua

Xue Xingkui

Gao Liang

Wu Wenjun

Han Xiaoyan

Cai Zhen

机构：

[1] Department of Hematology, School of Medicine, Zhejiang University

来源：

LEUKEMIA & LYMPHOMA | 2007年 / 48卷 / 05期

基金：

中国国家自然科学基金;

关键词：

homoharringtonine; apoptosis; ER stress; mitochondrial membrane potential; Bid;

D O I：

10.1080/10428190701216360

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Homoharringtonine has been shown to lead to apoptosis of leukemic cells in several studies. Here we showed that the endoplasmic reticulum (ER) may be the initial site of apoptotic signal induced by homoharringtonine in MUTZ-1 cells. After incubation with homoharringtonine, the percentage of apoptotic MUTZ-1 cells increased in a time-dependent manner, Ca 2+ translocated from ER pool to cytosol, the mitochondrial membrane potential decreased, and Bid protein translocated from ER to mitochondria. The activation of ER stress-associated proapoptotic factor CHOP and ER chaperones BiP and XBP1 genes followed by cleavage of caspase-3 but not caspase-4 protein were also observed.

引用

页码：964 / 977

页数：14

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