An ensemble of k-nearest neighbours algorithm for detection of Parkinson's disease

Parkinson's disease is a disease of the central nervous system that leads to severe difficulties in motor functions. Developing computational tools for recognition of Parkinson's disease at the early stages is very desirable for alleviating the symptoms. In this paper, we developed a discriminative model based on a selected feature subset and applied several classifier algorithms in the context of disease detection. All classifier performances from the point of both stand-alone and rotation-forest ensemble approach were evaluated on a Parkinson's disease data-set according to a blind testing protocol. The new method compared to hitherto methods outperforms the state-of-the-art in terms of both predictions of accuracy (98.46%) and area under receiver operating characteristic curve (0.99) scores applying rotation-forest ensemble k-nearest neighbour classifier algorithm.