Structural studies and antimicrobial properties of norcembrane diterpenoid from an Indian soft coral Sinularia inelegans Tixier-Durivault

被引：5
作者：
Singh, Keisham Sarjit [1 ]
Kaminsky, Werner H. [2 ]
Rodrigues, Celina [1 ]
Naik, C. G. [1 ]
机构：
[1] Natl Inst Oceanog, CSIR, Bioorgan Chem Lab, Panaji 403004, Goa, India
[2] Univ Washington, Dept Chem, Seattle, WA 98195 USA
来源：
JOURNAL OF CHEMICAL SCIENCES | 2009年 / 121卷 / 06期
关键词：
Diterpene; sinularia; stereochemistry; antimicrobial; crystallography; CEMBRANOID DITERPENES; FLEXIBILIDE;
D O I：
10.1007/s12039-009-0117-5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two metabolites featuring norcembranoid diterpene skeleton have been isolated from chloroform extract of soft coral of the genus sinularia, which was collected from the southern coast of India. The structures of the metabolites were determined by 1D, 2D NMR spectroscopic data and HRESIMS data analysis. The compounds have shown moderate-to-high antimicrobial activities. The structure and the relative stereochemistry of the metabolite 1 have been determined by X-ray crystallography.
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收藏
页码：1041 / 1046
页数：6
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