Development of immuno-oncology drugs - from CTLA4 to PD1 to the next generations

被引:485
作者
Hoos, Axel [1 ]
机构
[1] GlaxoSmithKline, Oncol Res & Dev, 1250 South Collegeville Rd, Collegeville, PA 19426 USA
关键词
IPILIMUMAB PLUS DACARBAZINE; LONG-TERM SURVIVAL; T-CELLS; CANCER-IMMUNOTHERAPY; PHASE-III; CHECKPOINT BLOCKADE; ADVANCED MELANOMA; DOUBLE-BLIND; METASTATIC MELANOMA; ANTI-PD-L1; ANTIBODY;
D O I
10.1038/nrd.2015.35
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Since the regulatory approval of ipilimumab in 2011, the field of cancer immunotherapy has been experiencing a renaissance. This success is based on progress in both preclinical and clinical science, including the development of new methods of investigation. Immuno-oncology has become a sub-specialty within oncology owing to its unique science and its potential for substantial and long-term clinical benefit. Immunotherapy agents do not directly attack the tumour but instead mobilize the immune system - this can be achieved through various approaches that utilize adaptive or innate immunity. Therefore, immuno-oncology drug development encompasses a broad range of agents, including antibodies, peptides, proteins, small molecules, adjuvants, cytokines, oncolytic viruses, bi-specific molecules and cellular therapies. This Perspective summarizes the recent history of cancer immunotherapy, including the factors that led to its success, provides an overview of novel drug-development considerations, summarizes three generations of immunotherapies that have been developed since 2011 and, thus, illustrates the breadth of opportunities these new generations of immunotherapies represent.
引用
收藏
页码:235 / 247
页数:13
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