BSA-conjugated CdS/Ag2S quantum dots: synthesis and preliminary antineoplastic assessment

被引：1
作者：
Wu, Sha-Sha [1 ]
Zhang, Jian-Zhou [2 ]
Yu, Xue-Hong [1 ]
Cao, Ying [1 ]
Wang, Hua-Jie [1 ,3 ]
机构：
[1] Henan Normal Univ, Sch Chem & Chem Engn, Minist Educ,Key Lab Green Chem Media & React, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Xinxiang 453007, Henan, Peoples R China
[2] Luoyang Inst Sci & Technol, Dept Environm Engn & Chem, Luoyang 471023, Peoples R China
[3] Xinxiang R&J Chem & Biotechnol Co Ltd, Xinxiang 453003, Peoples R China
来源：
RSC ADVANCES | 2014年 / 4卷 / 108期
基金：
中国国家自然科学基金;
关键词：
BOVINE SERUM-ALBUMIN; APOPTOTIC CELL-DEATH; DRUG-DELIVERY; CANCER-CELLS; IN-VIVO; NANOPARTICLES; CDS; SEMICONDUCTOR; CYTOTOXICITY; NANOCRYSTALS;
D O I：
10.1039/c4ra09526j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tumours are one of the most difficult diseases to cure, and traditional chemotherapy drugs are always intimidating for use in tumour treatments because of their highly toxic side effects. This drives the research and development of innovative drugs. As a product, nanomaterials, particularly nano-drugs, are exhibiting great potential for use in tumour treatments. Based on the understanding of the Trojan horse-antineoplastic mechanism of nano-drugs, we tried to introduce the drug-combination opinion into nano-drugs and successfully developed a facile and eco-friendly synthesis route to fabricate bovine serum albumin-conjugated CdS/Ag2S quantum dots. It is notable that the double metallic sulphides showed a synergistic inhibition between Cd2+ and Ag+ on rat pheochromocytoma ( PC 12) cells. Summarily, the present study substantiated the potential of synergistic anti-cancer opinion at the design of innovative nano-drugs with higher antineoplastic activity.
引用
收藏
页码：63502 / 63507
页数：6
相关论文
共 29 条
[1]   Effects of bovine serum albumin on the low temperature synthesis of barium titanate microparticles via a solid state route [J].
Ando, C ;
Kishi, H ;
Oguchi, H ;
Senna, M .
JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2006, 89 (05) :1709-1712
[2]   Surface-Charge-Dependent Cell Localization and Cytotoxicity of Cerium Oxide Nanoparticles [J].
Asati, Atul ;
Santra, Santimukul ;
Kaittanis, Charalambos ;
Perez, J. Manuel .
ACS NANO, 2010, 4 (09) :5321-5331
[3]   Bioconjugated quantum dots for cancer research: Present status, prospects and remaining issues [J].
Biju, Vasudevanpillai ;
Mundayoor, Sathish ;
Omkumar, Ramakrishnapillai V. ;
Anas, Abdulaziz ;
Ishikawa, Mitsuru .
BIOTECHNOLOGY ADVANCES, 2010, 28 (02) :199-213
[4]   Inhibition effects of protein-conjugated amorphous zinc sulfide nanoparticles on tumor cells growth [J].
Cao, Ying ;
Wang, Hua-Jie ;
Cao, Cui ;
Sun, Yuan-Yuan ;
Yang, Lin ;
Wang, Bao-Qing ;
Zhou, Jian-Guo .
JOURNAL OF NANOPARTICLE RESEARCH, 2011, 13 (07) :2759-2767
[5]   The Toxic Effects and Mechanisms of CuO and ZnO Nanoparticles [J].
Chang, Ya-Nan ;
Zhang, Mingyi ;
Xia, Lin ;
Zhang, Jun ;
Xing, Gengmei .
MATERIALS, 2012, 5 (12) :2850-2871
[6]   Cancer theranostics: the rise of targeted magnetic nanoparticles [J].
Cole, Adam J. ;
Yang, Victor C. ;
David, Allan E. .
TRENDS IN BIOTECHNOLOGY, 2011, 29 (07) :323-332
[7]   Enhanced photocatalytic activity and stability of semiconductor by Ag doping and simultaneous deposition: the case of CdS [J].
Huang, Sheng ;
Lin, Yu ;
Yang, Jianhua ;
Li, Xiangru ;
Zhang, Jun ;
Yu, Jiaguo ;
Shi, Honglong ;
Wang, Wenzhong ;
Yu, Ying .
RSC ADVANCES, 2013, 3 (43) :20782-20792
[8]   pH-Sensitive hydrogels based on bovine serum albumin for oral drug delivery [J].
Iemma, F ;
Spizzirri, UG ;
Puoci, F ;
Muzzalupo, R ;
Trombino, S ;
Cassano, R ;
Leta, S ;
Picci, N .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 312 (1-2) :151-157
[9]   Biological applications of quantum dots [J].
Jamieson, Timothy ;
Bakhshi, Raheleh ;
Petrova, Daniela ;
Pocock, Rachael ;
Imani, Mo ;
Seifalian, Alexander M. .
BIOMATERIALS, 2007, 28 (31) :4717-4732
[10]   Mannosylated chitosan-zinc sulphide nanocrystals as fluorescent bioprobes for targeted cancer imaging [J].
Jayasree, Aswathy ;
Sasidharan, Sajith ;
Koyakutty, Manzoor ;
Nair, Shantikumar ;
Menon, Deepthy .
CARBOHYDRATE POLYMERS, 2011, 85 (01) :37-43
123