Vitamin D and benign gynaecological diseases: a critical analysis of the current evidence

被引：13

作者：

Buggio, Laura ^{[1
]}

Roncella, Elena ^{[1
]}

Somigliana, Edgardo ^{[1
]}

Vercellini, Paolo ^{[1
]}

机构：

[1] Univ Milan, Dept Clin Sci & Community Hlth, Ist Ostetr & Ginecol Luigi Mangiagalli, I-20122 Milan, Italy

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2016年 / 32卷 / 04期

关键词：

uterine fibroids; overdiagnosis; vitamin D; polycystic ovary syndrome; Endometriosis; UTERINE LEIOMYOMA; D DEFICIENCY; ENDOMETRIOSIS; WOMEN; EXPRESSION; RECEPTOR; HEALTH; MODEL; REPRODUCTION; IMPLANTS;

D O I：

10.3109/09513590.2015.1111329

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vitamin D is a fat-soluble pro-hormone that plays an important role in bone homeostasis; beside this principal function, vitamin D promotes modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. In addition, several in vitro and in vivo studies have demonstrated that vitamin D deficiency could increase the risk of cancer, autoimmune and cardiovascular diseases. Moreover, vitamin D plays also an important role in female reproduction, because vitamin D receptors are expressed in ovarian tissue, endometrium, fallopian epithelial cells as well as in decidua and placenta. We aimed to review the most updated evidence, which suggests a link between vitamin D metabolism and the development of some gynaecological diseases, such as endometriosis, uterine fibroids and polycystic ovary syndrome.

引用

页码：259 / 263

页数：5