Vitamin D and benign gynaecological diseases: a critical analysis of the current evidence

被引：13
作者：
Buggio, Laura [1 ]
Roncella, Elena [1 ]
Somigliana, Edgardo [1 ]
Vercellini, Paolo [1 ]
机构：
[1] Univ Milan, Dept Clin Sci & Community Hlth, Ist Ostetr & Ginecol Luigi Mangiagalli, I-20122 Milan, Italy
来源：
GYNECOLOGICAL ENDOCRINOLOGY | 2016年 / 32卷 / 04期
关键词：
uterine fibroids; overdiagnosis; vitamin D; polycystic ovary syndrome; Endometriosis; UTERINE LEIOMYOMA; D DEFICIENCY; ENDOMETRIOSIS; WOMEN; EXPRESSION; RECEPTOR; HEALTH; MODEL; REPRODUCTION; IMPLANTS;
D O I：
10.3109/09513590.2015.1111329
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Vitamin D is a fat-soluble pro-hormone that plays an important role in bone homeostasis; beside this principal function, vitamin D promotes modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. In addition, several in vitro and in vivo studies have demonstrated that vitamin D deficiency could increase the risk of cancer, autoimmune and cardiovascular diseases. Moreover, vitamin D plays also an important role in female reproduction, because vitamin D receptors are expressed in ovarian tissue, endometrium, fallopian epithelial cells as well as in decidua and placenta. We aimed to review the most updated evidence, which suggests a link between vitamin D metabolism and the development of some gynaecological diseases, such as endometriosis, uterine fibroids and polycystic ovary syndrome.
引用
收藏
页码：259 / 263
页数：5
相关论文
共 51 条
[1]   Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis [J].
Abbas, Manal A. ;
Taha, Mutasem O. ;
Disi, Ahmad M. ;
Shomaf, Maha .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 715 (1-3) :72-75
[2]   Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1α-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers [J].
Agic, Admir ;
Xu, Hong ;
Altgassen, Christopher ;
Noack, Frank ;
Wolfler, Monika M. ;
Diedrich, Klaus ;
Friedrich, Michael ;
Taylor, Robert N. ;
Hornung, Daniela .
REPRODUCTIVE SCIENCES, 2007, 14 (05) :486-497
[3]   1,25-Dihydroxyvitamin D3 Regulates Expression of Sex Steroid Receptors in Human Uterine Fibroid Cells [J].
Al-Hendy, Ayman ;
Diamond, Michael P. ;
El-Sohemy, Ahmed ;
Halder, Sunil K. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (04) :E572-E582
[4]   Vitamin D in human reproduction: a narrative review [J].
Anagnostis, Panagiotis ;
Karras, Spyridon ;
Goulis, Dimitrios G. .
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2013, 67 (03) :225-235
[5]  
[Anonymous], 2010, DIETARY REFERENCE IN
[6]   Vitamin D status and ill health: a systematic review [J].
Autier, Philippe ;
Boniol, Mathieu ;
Pizot, Cecile ;
Mullie, Patrick .
LANCET DIABETES & ENDOCRINOLOGY, 2014, 2 (01) :76-89
[7]   Vitamin D and the Risk of Uterine Fibroids [J].
Baird, Donna Day ;
Hill, Michael C. ;
Schectman, Joel M. ;
Hollis, Bruce W. .
EPIDEMIOLOGY, 2013, 24 (03) :447-453
[8]   The rise and rise of vitamin D testing [J].
Bilinski, Kellie ;
Boyages, Steven .
BMJ-BRITISH MEDICAL JOURNAL, 2012, 345
[9]   Representations of the health value of vitamin D supplementation in newspapers: media content analysis [J].
Caulfield, Timothy ;
Clark, Marianne I. ;
McCormack, James P. ;
Rachul, Christen ;
Field, Catherine J. .
BMJ OPEN, 2014, 4 (12)
[10]   The Role of Vitamin D in Reproductive Health-A Trojan Horse or the Golden Fleece? [J].
Dabrowski, Filip A. ;
Grzechocinska, Barbara ;
Wielgos, Miroslaw .
NUTRIENTS, 2015, 7 (06) :4139-4153
123456