Polygenic Epidemiology

被引:114
作者
Dudbridge, Frank [1 ]
机构
[1] London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, Keppel St, London WC1E 7HT, England
基金
英国医学研究理事会;
关键词
missing heritability; genetic correlation; genetic risk prediction; Mendelian randomization; GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; MULTIVARIABLE MENDELIAN RANDOMIZATION; PLEIOTROPIC GENETIC-VARIANTS; PROSTATE-CANCER; COMPLEX TRAITS; INSTRUMENTAL VARIABLES; MULTIPLE-SCLEROSIS; HUMAN HEIGHT; COMMON SNPS;
D O I
10.1002/gepi.21966
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Much of the genetic basis of complex traits is present on current genotyping products, but the individual variants that affect the traits have largely not been identified. Several traditional problems in genetic epidemiology have recently been addressed by assuming a polygenic basis for disease and treating it as a single entity. Here I briefly review some of these applications, which collectively may be termed polygenic epidemiology. Methodologies in this area include polygenic scoring, linear mixed models, and linkage disequilibrium scoring. They have been used to establish a polygenic effect, estimate genetic correlation between traits, estimate how many variants affect a trait, stratify cases into subphenotypes, predict individual disease risks, and infer causal effects using Mendelian randomization. Polygenic epidemiology will continue to yield useful applications even while much of the specific variation underlying complex traits remains undiscovered.
引用
收藏
页码:268 / 272
页数:5
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