Conductive PEDOT:PSS coated polylactide (PLA) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) electrospun membranes: Fabrication and characterization

被引：56

作者：

Chang, Hui Chung ^{[1
]}

Sun, Tao ^{[2
]}

Sultana, Naznin ^{[1
,3
]}

Lim, Mim Mim ^{[1
]}

Khan, Tareef Hayat ^{[4
]}

Ismail, Ahmad Fauzi ^{[3
]}

机构：

[1] Univ Teknol Malaysia, Fac Biosci & Med Engn, Skudai 81300, Johor, Malaysia

[2] ASTAR, Inst Microelect, Miniaturized Med Devices Program, Singapore, Singapore

[3] Univ Teknol Malaysia, Adv Membrane Technol Res Ctr, Skudai 81300, Johor, Malaysia

[4] Univ Teknol Malaysia, Fac Alam Bina, KALAM, Skudai 81300, Johor, Malaysia

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 61卷

关键词：

Electrospinning; Scaffold; Polylactide; Poly(3-hydroxybutyrate-co-3-hydroxyvalerate); PEDOT:PSS; IN-VITRO; TISSUE; MORPHOLOGY; SCAFFOLDS; FIBERS;

D O I：

10.1016/j.msec.2015.12.074

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In the current study, electrospinning technique was used to fabricate composite membranes by blending of a synthetic polymer, polylactic acid (PLA) and a natural polymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate), PHBV. Conductive membranes were prepared by dipping PLA/PHBV electrospun membranes into poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) solution, which is a biocompatible polymer. The coated and uncoated membranes were evaluated using several techniques. The electrical conductivity of the coated membranes was measured using a digital multimeter. In vitro cell cytotoxicity and cell viability were measured by culturing human skin fibroblast (HSF) cells onto the membranes using MTF assays. It was observed that electrospinning of 20% (w/v) PLA/PHBV with a weight ratio of 50:50 produced the most uniform fibers with no beads. It was observed that the wettability and surface roughness of the PEDOT:PSS coated PLA/PHBV membranes were greatly increased than uncoated membrane. The results of cell viability using MIT assay, cell attachment and cell proliferation showed that the conductive PEDOT:PSS coated PLA/PHBV membrane were more favorable for tissue engineering application than their uncoated counterparts. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：396 / 410

页数：15

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