Synthesis of Asymmetrical 2,6-Diarylpyridines from Linear α,β,γ,δ-Unsaturated Ketones by Addition of Ammonium Formate Followed by Annulation

被引：5

作者：

Gao, Yejun ^{[1
,2
]}

Chen, Rener ^{[1
]}

Ma, Yongmin ^{[1
,2
]}

机构：

[1] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Peoples R China

[2] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2019年 / 51卷 / 20期

关键词：

regioselectivity; Michael addition; annulations; 2; 4-dien-1-one; asymmetrical pyridine; CHICHIBABIN PYRIDINE SYNTHESIS; ONE-POT SYNTHESIS; VILSMEIER-HAACK REACTIONS; C-H FUNCTIONALIZATION; 2,4-AND 2,6-DIARYLPYRIDINES; SUBSTITUTED PYRIDINES; AROMATIC KETONES; DERIVATIVES; ACIDS; ISODESMOSINE;

D O I：

10.1055/s-0037-1610725

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method has been established for the synthesis of asymmetrical 2,6-diarylpyridines by cyclization of alpha,beta,gamma,delta-unsaturated ketones with ammonium formate under air atmosphere. The reaction is metal-free and operationally convenient from readily available starting materials. Thirty-three examples have been presented, most of which show good yields.

引用

页码：3875 / 3882

页数：8

共 75 条

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