Emerging SARS-CoV-2 Variants and Impact in Global Vaccination Programs against SARS-CoV-2/COVID-19

被引：202

作者：

Gomez, Carmen Elena ^{[1
]}

Perdiguero, Beatriz ^{[1
]}

Esteban, Mariano ^{[1
]}

机构：

[1] CSIC, CNB, Ctr Nacl Biotecnol, Dept Mol & Cellular Biol, Campus Cantoblanco, Madrid 28049, Spain

来源：

VACCINES | 2021年 / 9卷 / 03期

关键词：

SARS-CoV-2; COVID-19; variant; spike protein; mutation; lineage; vaccine efficacy; neutralizing antibodies; RECEPTOR-BINDING DOMAIN; MUTATIONS; SPIKE;

D O I：

10.3390/vaccines9030243

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants in different continents is causing a major concern in human global health. These variants have in common a higher transmissibility, becoming dominant within populations in a short time, and an accumulation of a high number of mutations in the spike (S) protein, especially within the amino terminal domain (NTD) and the receptor binding domain (RBD). These mutations have direct implications on virus infection rates through higher affinity of S RBD for the cellular angiotensin-converting enzyme-2 (ACE-2) receptor. There are also signs of enhanced virulence, re-infection frequency, and increased resistance to the action of monoclonal and polyclonal antibodies from convalescence sera and in vaccinated individuals in regions where the variants spread dominantly. In this review, we describe the different SARS-CoV-2 variants that have thus far been identified in various parts of the world with mutational changes and biological properties as well as their impact in medical countermeasures and human health.

引用

页码：1 / 13

页数：13

共 49 条

[31] Hospitalization and mortality associated with SARS-CoV-2 viral clades in COVID-19 [J].

Nakamichi, Kenji ;

Shen, Jolie Z. ;

Lee, Cecilia S. ;

Lee, Aaron ;

Roberts, Emma A. ;

Simonson, Paul D. ;

Roychoudhury, Pavitra ;

Andriesen, Jessica ;

Randhawa, April K. ;

Mathias, Patrick C. ;

Greninger, Alex L. ;

Jerome, Keith R. ;

Van Gelder, Russell N. .

SCIENTIFIC REPORTS, 2021, 11 (01)

[32]

Nelson G., 2021, MOL DYNAMIC SIMULATI, DOI 10.1101/2021.01.13.426558

[33]

O'Grady NP, 2002, CLIN INFECT DIS, V35, P1281, DOI [10.1086/344188, 10.1086/502007]

[34] Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands [J].

Oude Munnink, Bas B. ;

Nieuwenhuijse, David F. ;

Stein, Mart ;

O'Toole, Aine ;

Haverkate, Manon ;

Mollers, Madelief ;

Kamga, Sandra K. ;

Schapendonk, Claudia ;

Pronk, Mark ;

Lexmond, Pascal ;

van der Linden, Anne ;

Bestebroer, Theo ;

Chestakova, Irina ;

Overmars, Ronald J. ;

van Nieuwkoop, Stefan ;

Molenkamp, Richard ;

van der Eijk, Annemiek A. ;

GeurtsvanKessel, Corine ;

Vennema, Harry ;

Meijer, Adam ;

Rambaut, Andrew ;

van Dissel, Jaap ;

Sikkema, Reina S. ;

Timen, Aura ;

Koopmans, Marion .

NATURE MEDICINE, 2020, 26 (09) :1405-1410

[35] Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies [J].

Planas, Delphine ;

Bruel, Timothee ;

Grzelak, Ludivine ;

Guivel-Benhassine, Florence ;

Staropoli, Isabelle ;

Porrot, Francoise ;

Planchais, Cyril ;

Buchrieser, Julian ;

Rajah, Maaran Michael ;

Bishop, Elodie ;

Albert, Melanie ;

Donati, Flora ;

Prot, Matthieu ;

Behillil, Sylvie ;

Enouf, Vincent ;

Maquart, Marianne ;

Smati-Lafarge, Mounira ;

Varon, Emmanuelle ;

Schortgen, Frederique ;

Yahyaoui, Layla ;

Gonzalez, Maria ;

De Seze, Jerome ;

Pere, Helene ;

Veyer, David ;

Seve, Aymeric ;

Simon-Loriere, Etienne ;

Fafi-Kremer, Samira ;

Stefic, Karl ;

Mouquet, Hugo ;

Hocqueloux, Laurent ;

van der Werf, Sylvie ;

Prazuck, Thierry ;

Schwartz, Olivier .

NATURE MEDICINE, 2021, 27 (05) :917-+

[36] Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine [J].

Polack, Fernando P. ;

Thomas, Stephen J. ;

Kitchin, Nicholas ;

Absalon, Judith ;

Gurtman, Alejandra ;

Lockhart, Stephen ;

Perez, John L. ;

Perez Marc, Gonzalo ;

Moreira, Edson D. ;

Zerbini, Cristiano ;

Bailey, Ruth ;

Swanson, Kena A. ;

Roychoudhury, Satrajit ;

Koury, Kenneth ;

Li, Ping ;

Kalina, Warren V. ;

Cooper, David ;

Frenck, Robert W., Jr. ;

Hammitt, Laura L. ;

Tureci, Ozlem ;

Nell, Haylene ;

Schaefer, Axel ;

Unal, Serhat ;

Tresnan, Dina B. ;

Mather, Susan ;

Dormitzer, Philip R. ;

Sahin, Ugur ;

Jansen, Kathrin U. ;

Gruber, William C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) :2603-2615

[37] Resurgence of COVID-19 in Manaus, Brazil, despite high seroprevalence [J].

Sabino, Ester C. ;

Buss, Lewis F. ;

Carvalho, Maria P. S. ;

Prete, Carlos A., Jr. ;

Crispim, Myuki A. E. ;

Fraiji, Nelson A. ;

Pereira, Rafael H. M. ;

Parag, Kris V. ;

Peixoto, Pedro da Silva ;

Kraemer, Moritz U. G. ;

Oikawa, Marcio K. ;

Salomon, Tassila ;

Cucunuba, Zulma M. ;

Castro, Marcia C. ;

Santos, Andreza Aruska de Souza ;

Nascimento, Vitor H. ;

Pereira, Henrique S. ;

Ferguson, Neil M. ;

Pybus, Oliver G. ;

Kucharski, Adam ;

Busch, Michael P. ;

Dye, Christopher ;

Faria, Nuno R. .

LANCET, 2021, 397 (10273) :452-455

[38] Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis [J].

Shannon, Ashleigh ;

Selisko, Barbara ;

Nhung-Thi-Tuyet Le ;

Huchting, Johanna ;

Touret, Franck ;

Piorkowski, Geraldine ;

Fattorini, Veronique ;

Ferron, Francois ;

Decroly, Etienne ;

Meier, Chris ;

Coutard, Bruno ;

Peersen, Olve ;

Canard, Bruno .

NATURE COMMUNICATIONS, 2020, 11 (01)

[39]

Shinde V., 2021, JACC-BASIC TRANSL SC, DOI DOI 10.1016/J.JACBTS.2020.10.003

[40] Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding [J].

Starr, Tyler N. ;

Greaney, Allison J. ;

Hilton, Sarah K. ;

Ellis, Daniel ;

Crawford, Katharine H. D. ;

Dingens, Adam S. ;

Navarro, Mary Jane ;

Bowen, John E. ;

Tortorici, M. Alejandra ;

Walls, Alexandra C. ;

King, Neil P. ;

Veesler, David ;

Bloom, Jesse D. .

CELL, 2020, 182 (05) :1295-+

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