Genetic Networks Lead and Follow Tumor Development: MicroRNA Regulation of Cell Cycle and Apoptosis in the p53 Pathways

被引:35
作者
Otsuka, Kurataka [1 ,2 ]
Ochiya, Takahiro [1 ]
机构
[1] Natl Canc Ctr, Div Mol & Cellular Med, Chuo Ku, Tokyo 1040045, Japan
[2] Kewpie Corp, Div Res & Dev, Chofu, Tokyo 1820002, Japan
关键词
EPITHELIAL-MESENCHYMAL TRANSITION; FACTOR-BINDING-SITES; DOWN-REGULATION; C-MYC; MIR-200; FAMILY; LUNG-CANCER; POSTTRANSCRIPTIONAL REGULATION; P53-INDUCIBLE MICRORNAS; NEGATIVE REGULATION; FEEDBACK CIRCUITRY;
D O I
10.1155/2014/749724
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
During the past ten years, microRNAs (miRNAs) have been shown to play a more significant role in the formation and progression of cancer diseases than previously thought. With an increase in reports about the dysregulation of miRNAs in diverse tumor types, it becomes more obvious that classic tumor-suppressive molecules enter deep into the world of miRNAs. Recently, it has been demonstrated that a typical tumor suppressor p53, known as the guardian of the genome, regulates some kinds of miRNAs to contribute to tumor suppression by the induction of cell-cycle arrest and apoptosis. Meanwhile, miRNAs directly/indirectly control the expression level and activity of p53 to fine-tune its functions or to render p53 inactive, indicating that the interplay between p53 and miRNA is overly complicated. The findings, along with current studies, will underline the continuing importance of understanding this interlocking control system for future therapeutic strategies in cancer treatment and prevention.
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页数:10
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