Targeting the IL-33/IL-13 Axis for Respiratory Viral Infections

被引：36

作者：

Donovan, Chantal ^{[1
,2
]}

Bourke, Jane E. ^{[1
,2
]}

Vlahos, Ross ^{[2
,3
]}

机构：

[1] Monash Univ, Dept Pharmacol, Biomed Discovery Inst, Clayton, Vic 3800, Australia

[2] Univ Melbourne, Lung Hlth Res Ctr, Dept Pharmacol & Therapeut, Melbourne, Vic 3010, Australia

[3] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2016年 / 37卷 / 04期

关键词：

INDUCED AIRWAY HYPERRESPONSIVENESS; INFLUENZA-VIRUS INFECTION; GOBLET CELL HYPERPLASIA; INNATE LYMPHOID-CELLS; CIGARETTE-SMOKE; EPITHELIAL-CELLS; ASTHMA EXACERBATIONS; DENDRITIC CELLS; GUINEA-PIG; IL-33;

D O I：

10.1016/j.tips.2016.01.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are highly prevalent worldwide. One of the major factors that limits the efficacy of current medication in these patients are viral infections, leading to exacerbations of symptoms and decreased quality of life. Current pharmacological strategies targeting virus-induced lung disease are problematic due to antiviral resistance and the requirement for strain-specific vaccination. Thus, new therapeutic strategies are urgently required. In this Opinion article, we provide state-of-the-art evidence from humans and preclinical animal models implicating the interleukin (IL)-33/IL-13 axis in virus-induced lung disease. Thus, targeting the IL-33/IL-13 axis may be a feasible way to overcome the limitations of current therapy used to treat virus-induced exacerbations of lung disease.

引用

页码：252 / 261

页数：10

共 98 条

[91] Critical role for IL-13 in the development of allergen-induced airway hyperreactivity [J].