Body mass index and prognosis in patients with head and neck cancer

被引：72

作者：

Gama, Ricardo Ribeiro ^{[1
]}

Song, Yuyao ^{[2
,3
]}

Zhang, Qihuang ^{[2
,3
]}

Brown, M. Catherine ^{[3
,4
]}

Wang, Jennifer ^{[5
,6
]}

Habbous, Steven ^{[3
,4
]}

Tong, Li ^{[3
,4
]}

Huang, Shao Hui ^{[7
]}

O'Sullivan, Brian ^{[7
]}

Waldron, John ^{[7
]}

Xu, Wei ^{[2
,3
]}

Goldstein, David ^{[5
,6
]}

Liu, Geoffrey ^{[3
,4
]}

机构：

[1] Barretos Canc Hosp, Head & Neck Surg Dept, Barretos, Brazil

[2] Univ Toronto, Biostat Dept, Princess Margaret Canc Ctr, Toronto, ON, Canada

[3] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[4] Univ Toronto, Princess Margaret Canc Ctr, Dept Med, Toronto, ON, Canada

[5] Univ Hlth Network, Dept Otolaryngol & Head & Neck Surg, Toronto, ON, Canada

[6] Univ Toronto, Toronto, ON, Canada

[7] Univ Toronto, Dept Radiat Oncol, Princess Margaret Canc Ctr, Toronto, ON, Canada

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 06期

关键词：

head and neck cancer; prognosis; clinical outcomes; body mass index; squamous cell carcinoma; SQUAMOUS-CELL CARCINOMAS; HUMAN-PAPILLOMAVIRUS; INTERNATIONAL HEAD; POOLED ANALYSIS; ORAL-CAVITY; SURVIVAL; OBESITY; RISK; MORTALITY; ADULTHOOD;

D O I：

10.1002/hed.24760

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Body mass index (BMI) has been associated variably with head and neck cancer outcomes. We evaluated the association between BMI at either diagnosis or at early adulthood head and neck cancer outcomes. Methods. Patients with invasive head and neck squamous cell cancer at Princess Margaret Cancer Centre in Toronto, Canada, were surveyed on tobacco and alcohol exposure, performance status, comorbidities, and BMI at diagnosis. A subset also had data collected for BMI at early adulthood. Results. With a median follow-up of 2.5 years, in 1279 analyzed patients, being overweight (hazard ratio [HR], 0.55; 95% confidence interval [CI], 0.4-0.8; p = .001) at diagnosis was associated with improved survival when compared with individuals with normal weight. In contrast, underweight patients at diagnosis were associated with a worse outcome (HR, 1.89; 95% CI, 1.2-3.1; p < .01). Conclusion. Being underweight at diagnosis was an independent, adverse prognostic factor, whereas being overweight conferred better prognosis. BMI in early adulthood was not associated strongly with head and neck cancer outcomes. (C) 2017 Wiley Periodicals, Inc.

引用

页码：1226 / 1233

页数：8

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