[6-13C]-(2S,4S)-5-chloroleucine:: synthesis and incubation studies with cultures of the cyanobacterium, Lyngbya majuscula

被引：16

作者：

Gerwick, WH

Leslie, P

Long, GC

Marquez, BL

Willis, CL

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(02)02572-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[6-C-13]-(2S,4S)-5-Chloroleucine 12 was prepared in six steps and 26% overall yield from protected L-glutamic acid using (CH3I)-C-13 as the source of isotopic label. On feeding 12 to cultures of L. majuscula no incorporation of isotopic label into the trichlorinated marine natural product barbamide as detected. The synthesis of a novel dichloro amino acid 16 is also described. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：285 / 288

页数：4

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