Fluorescent small-molecule probes of biochemistry at the plasma membrane

被引：51
作者：
Cairo, Christopher W. [1 ]
Key, Jessie A.
Sadek, Christopher M.
机构：
[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2010年 / 14卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
IN-VITRO; PROTEIN; SURFACE; RECEPTORS; ANALOG; ACETYLCHOLINE; VISUALIZATION; SUBSTRATE; CERAMIDE; MOBILITY;
D O I：
10.1016/j.cbpa.2009.09.032
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The function of cellular membranes remains a critical area of study. Advances in molecular biology and biochemistry have helped to define the plasma membrane as a dynamic and heterogeneous structure. Probes capable of resolving molecular interactions and biochemical changes within the membrane are becoming a necessary tool for cell biology studies. We review current examples that apply small molecule fluorophores to label either lipids or proteins to study the plasma membrane. We discuss probes of the lipid environment itself, as well as labeling strategies for membrane proteins and membrane receptors.
引用
收藏
页码：57 / 63
页数：7
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