Rapamycin for longevity: opinion article

被引：136
作者：
Blagosklonny, Mikhail V. [1 ]
机构：
[1] Roswell Park Canc Inst, Cell Stress Biol, Buffalo, NY 14263 USA
来源：
AGING-US | 2019年 / 11卷 / 19期
关键词：
rapamycin; rapalogs; metformin; aging; anti-aging; fasting; lifespan; health span; EXTENDS LIFE-SPAN; DIABETIC KIDNEY-DISEASE; LONG-TERM TREATMENT; MAMMALIAN TARGET; DIETARY RESTRICTION; INSULIN-RESISTANCE; TRANSPLANT RECIPIENTS; CELLULAR SENESCENCE; CALORIC RESTRICTION; MTOR INHIBITION;
D O I：
10.18632/aging.102355
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
From the dawn of civilization, humanity has dreamed of immortality. So why didn't the discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will discuss several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today. Furthermore, the alternative to the reversible (and avoidable) side effects of rapamycin/everolimus are the irreversible (and inevitable) effects of aging: cancer, stroke, infarction, blindness and premature death. I will also discuss why it is more dangerous not to use anti-aging drugs than to use them and how rapamycin-based drug combinations have already been implemented for potential life extension in humans. If you read this article from the very beginning to its end, you may realize that the time is now.
引用
收藏
页码：8048 / 8067
页数：20
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