Impact of interventions to reduce Alzheimer's disease pathology on the prevalence of dementia in the oldest-old

被引：33

作者：

Brookmeyer, Ron ^{[1
]}

Kawas, Claudia H. ^{[2
,3
,4
]}

Abdallah, Nada ^{[1
]}

Paganini-Hill, Annlia ^{[2
]}

Kim, Ronald C. ^{[5
]}

Corrada, Maria M. ^{[2
,4
,6
]}

机构：

[1] Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA USA

[2] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA

[3] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA USA

[4] Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Irvine, CA USA

[5] Univ Calif Irvine, Med Ctr, Dept Pathol, Orange, CA USA

[6] Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA

来源：

ALZHEIMERS & DEMENTIA | 2016年 / 12卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; Dementia; Intervention; Oldest-old; Pathology; Prediction; Prevalence; Prevention; NEUROPATHOLOGIC ASSESSMENT; NATIONAL INSTITUTE; AGE; COMMON; MODEL; RISK;

D O I：

10.1016/j.jalz.2016.01.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: The number of persons aged >90 years will grow significantly in coming decades. This group has the highest rates of dementia, most commonly Alzheimer's disease (AD). Methods: Using The 90+ Study, we developed a statistical model for dementia risk based on brain pathologies. Intervention scenarios which reduce or eliminate AD pathology were considered, and the numbers of dementia cases among the U.S. oldest-old that could be prevented were estimated. Results: The U.S. dementia prevalence among the oldest-old will increase from 1.35 million in 2015 to 4.72 million in 2050. If interventions eliminate AD pathology, dementia prevalence would be reduced by approximately 50%, averting nearly 2.4 million cases in 2050. However, large numbers of dementia cases would still remain. Discussion: Reducing AD pathology would significantly decrease the public health burden of dementia. However, other interventions are needed to address the burden associated with other dementing pathologies prevalent in the oldest-old. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：225 / 232

页数：8

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