Oxygen therapy in traditional and immunotherapeutic treatment protocols of cancer patients: current reality and future prospects

被引:8
作者
Seledtsov, Victor Ivanovich [1 ,2 ]
von Delwig, Alexei A. [1 ]
机构
[1] Innovita Res Co, Dept Immunol, Vilnius, Lithuania
[2] Russian Acad Sci, Ctr Immunotherapy, Cent Clin Hosp, Moscow, Russia
关键词
Reactive oxygen species; oxidative stress; cancer; chemoradiotherapy; immunotherapy; hyperthermia; HYPERBARIC-OXYGEN; OZONE THERAPY; OXIDATIVE STRESS; HYPERTHERMIA; MECHANISMS; APOPTOSIS; EFFICACY; HYPOXIA; INNATE; SAFETY;
D O I
10.1080/14737140.2022.2070153
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Introduction The metabolic environment in ischemic and hypoxic tumors is known to contribute to cancer progression. Importantly, peculiar metabolic changes occurring in malignant cells (the increased glycolysis and the hampered Krebs cycle) may contribute to decreased antioxidant-dependent defense in ischemic and hypoxic tumors. Areas covered In the clinic, oxygen saturation of tumors is usually achieved by the application of water-soluble ozone and hyperbaric oxygen therapy. Tumor oxygenation has been shown to inhibit tumor growth and potentiate anti-tumor effects of chemoradiotherapy in animal experiments and the clinical setting. Tumor oxygenation could enhance anti-tumor effects achieved by tumor blood vessel occlusion or angiostatic therapy. Expert opinion Owing to a profound influence of ROS on both the innate and adaptive immunity, oxygen therapy, when combined simultaneously or sequentially with immunotherapeutic interventions (such as immune checkpoint inhibition, drug-induced immunostimulation, adoptive cell therapy, hyperthermia, etc.), could be considered as a novel highly-effective clinical biological approach to cancer treatment.
引用
收藏
页码:575 / 581
页数:7
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