OXPHOS Supercomplexes Respiration and Life-Span Control in the Aging Model Podospora anserina

被引：18

作者：

Krause, Frank ^{[1
]}

Scheckhuber, Christian Q. ^{[2
]}

Werner, Alexandra ^{[2
]}

Rexroth, Sascha ^{[1
]}

Reifschneider, Nicole H. ^{[1
]}

Dencher, Norbert A. ^{[1
]}

Osiewacz, Heinz D. ^{[2
]}

机构：

[1] Tech Univ Darmstadt, Dept Chem, D-64287 Darmstadt, Germany

[2] Goethe Univ Frankfurt, Inst Bot, D-60439 Frankfurt, Germany

来源：

UNDERSTANDING AND MODULATING AGING | 2006年 / 1067卷

关键词：

aging; alternative oxidase; blue-native electrophoresis; colorless-native electrophoresis; complex I; complex III; cytochrome oxidase; mitochondria; oxidative phosphorylation; respirasome; supercomplex;

D O I：

10.1196/annals.1354.013

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Recent biochemical evidence has indicated the existence of respiratory supercomplexes as well as ATP synthase oligomers in the inner mitochondrial membrane of different eukaryotes. We have studied the organization of the respiratory chain of a wild-type strain and of two long-lived mutants of the filamentous fungus Podospora anserina. This aging model is able to respire by either the standard or the alternative pathway. In the latter, electrons are directly transferred from ubiquinol to the alternative oxidase (AOX) and thus bypass complexes III and IV. We showed that the two pathways are composed of distinct respiratory supercomplexes. These data are of significance for the understanding of both respiratory pathways as well as of life-span control and aging.

引用

页码：106 / 115

页数：10

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