The Effect of Preoperative Apolipoprotein A-I on the Prognosis of Surgical Renal Cell Carcinoma A Retrospective Large Sample Study

被引：28

作者：

Guo, Shengjie ^{[1
]}

He, Xiaobo ^{[2
]}

Chen, Qian ^{[3
]}

Yang, Guangwei ^{[2
]}

Yao, Kai ^{[1
]}

Dong, Pei ^{[1
]}

Ye, Yunlin ^{[1
]}

Chen, Dong ^{[1
]}

Zhang, Zhiling ^{[1
]}

Qin, Zike ^{[1
]}

Liu, Zhuowei ^{[1
]}

Li, Zaishang ^{[1
]}

Xue, Yunfei ^{[4
]}

Zhang, Meng ^{[4
]}

Liu, Ruiwu ^{[5
]}

Zhou, Fangjian ^{[1
]}

Han, Hui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, Dept Urol,State Key Lab Oncol South China, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Med Oncol, Zhuhai, Peoples R China

[3] Sun Yat Sen Univ, Xinhua Coll, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Sch Med, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[5] Univ Calif Davis, Dept Biochem & Mol Med, Sacramento, CA 95817 USA

来源：

MEDICINE | 2016年 / 95卷 / 12期

基金：

中国国家自然科学基金;

关键词：

DENSITY-LIPOPROTEIN CHOLESTEROL; BREAST-CANCER; SERUM HDL; APOA-I; RISK;

D O I：

10.1097/MD.0000000000003147

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prognostic value of serum lipid-profile in renal cell cancer (RCC) remains unknown. The purpose of the study is to explore the association between the serum lipid-profile and RCC patients. The levels of preoperative serum lipid-profile (including cholesterol, triglycerides, high-density lipoprotein-cholesterol [HDL-C], low-density lipoprotein-cholesterol [LDL-C], apolipoprotein A-I [ApoA-I], and apolipoprotein B [ApoB]) were retrospectively performed in 786 patients with RCC. The cutoff values of the lipids were determined by the receiver-operating characteristic (ROC) curve analysis. Univariate and multivariate Cox regression analyses were performed to investigate the prognostic value of serum lipids in RCC. Combined ROC analysis and univariate and multivariate Cox regression analyses, for overall survival (OS), revealed patients with low ApoA-I (<1.04) had significantly lower OS than the high ApoA-I (1.04) group (multivariate Cox regression analyses, hazard ratio [HR], 0.57; P=0.003). Not only in the whole RCC cohort but also in the subgroups stratified according to the pT1-2 (P=0.002), pN0 (P<0.001), and pM0 (P=0.001) status, respectively. Moreover, in the 755 patients with nonmetastasis, the low ApoA-I group was also associated with shortened disease-free survival (DFS) time compared to the high ApoA-I group (multivariate Cox regression analyses, HR, 0.65; P=0.033). However, the other lipids were not independent prognostic factors for surgical RCC. An elevated level of preoperative ApoA-I was demonstrated to be related with better survival in patients with surgical RCC. Measuring the preoperative ApoA-I might be a simple way for finding the poor prognostic patients who should enrolled in further clinical trials and management.

引用

页数：11

共 34 条

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