Association between genetic variation in the oxytocin receptor gene and emotional withdrawal, but not between oxytocin pathway genes and diagnosis in psychotic disorders

被引:25
作者
Haram, Marit [1 ,2 ]
Tesli, Martin [1 ,2 ]
Bettella, Francesco [1 ,2 ]
Djurovic, Srdjan [1 ,2 ,3 ]
Andreassen, Ole Andreas [1 ,2 ]
Melle, Ingrid [1 ,2 ]
机构
[1] Univ Oslo, NORMENT, KG Jebsen Ctr Psychosis Res, Inst Clin Med, N-0424 Oslo, Norway
[2] Oslo Univ Hosp, Div Mental Hlth & Addict, N-0450 Oslo, Norway
[3] Univ Oslo, Ulleval Hosp, Dept Med Genet, N-0424 Oslo, Norway
关键词
oxytocin; vasopressin; schizophrenia; psychotic disorders; single nucleotide polymoiphisms; polygenic risk score; NEGATIVE SYNDROME SCALE; INTRANASAL OXYTOCIN; SOCIAL-PERCEPTION; BIPOLAR DISORDER; 1ST-EPISODE PSYCHOSIS; HEALTHY CONTROLS; DOUBLE-BLIND; OXTR GENE; SCHIZOPHRENIA; RISK;
D O I
10.3389/fnhum.2015.00009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Social dysfunction is common in patients with psychotic disorders. Oxytocin is a neuropeptide with a central role in social behavior. This study aims to explore the relationship between oxytocin pathway genes and symptoms related to social dysfunction in patients with psychotic disorders. We performed association analyses between four oxytocin pathway genes (OXT, OXTR, AVP and CD38) and four areas of social behavior-related psychopathology as measured by Positive and Negative Syndrome Scale. For this purpose, we used both a polygenic risk score (PGRS) and single OXTR candidate single nucleotide polymorphism previously reported in the literature (rs53576, rs237902, and rs2254298). A total of 734 subjects with DSM-IV psychotic spectrum disorders and 420 healthy controls were included. Oxytocin pathway PGRSs were calculated based on the independent Psychiatric Genomics Consortium study sample. There was a significant association between symptom of Emotional Withdrawal and the previously reported OXTR risk allele A in rs53576. No significant associations between oxytocin pathway gene variants and a diagnosis of psychotic disorder were found. Our findings indicate that while oxytocin pathway genes do not appear to contribute to the susceptibility to psychotic disorders, variations in the OXTR gene might play a role in the development of impaired social behavior.
引用
收藏
页码:1 / 7
页数:7
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