A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery

被引：48

作者：

Zeng, Xiaodong ^{[1
,2
,3
]}

Xie, Liru ^{[1
]}

Chen, Deliang ^{[4
]}

Li, Shanshan ^{[2
]}

Nong, Jinxia ^{[2
]}

Wang, Bo ^{[1
]}

Tang, Lin ^{[2
]}

Li, Qianqian ^{[2
]}

Li, Yang ^{[2
]}

Deng, Zixin ^{[2
,3
]}

Hong, Xuechuan ^{[2
,3
,5
]}

Wu, Mingfu ^{[1
,3
]}

Xiao, Yuling ^{[2
,3
]}

机构：

[1] Huazhong Univ Sci & Technol, State Key Lab Virol, Dept Gynecol, Canc Biol Res Ctr,Tongji Hosp,Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

[2] Wuhan Univ, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Key Lab Combinatorial Biosynth & Drug Discovery M, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China

[3] Tibet Univ, Coll Med, Innovat Ctr Tradit Tibetan Med Modernizat & Qual, Lhasa 850000, Xizang, Peoples R China

[4] Gannan Normal Univ, Chem & Chem Engn Coll, Jiangxi Key Lab Organopharmaceut Chem, Ganzhou 341000, Jiangxi, Peoples R China

[5] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Sichuan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 95期

关键词：

IN-VIVO; FLUOROPHORES; CANCER; BREAKTHROUGH; DESIGN; DOTS;

D O I：

10.1039/c9cc07694h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel bright near-infrared II (NIR-II, 1000-1700 nm) fluorescent probe with excellent water-solubility, superior photostability, and excellent in vitro and in vivo biocompatibility was facilely synthesized for in vivo biomedical imaging of xenograft breast tumor and chemically induced spontaneous breast carcinoma. To the best of our knowledge, it is the first time that the superior practical applications of this NIR-II probe in dimethylbenzanthracene (DMBA)-induced rat mammary carcinoma imaging and image-guided rat carcinoma surgery were demonstrated.

引用

页码：14287 / 14290

页数：4

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