First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner

被引：52
作者：
Ishii, K.
Kikuchi, Y.
Matsuyama, S.
Kanai, Y.
Kotani, K.
Ito, T.
Yamazaki, H.
Funaki, Y.
Iwata, R.
Itoh, M.
Yanai, K.
Hatazawa, J.
Itoh, N.
Tanizaki, N.
Amano, D.
Yamada, M.
Yamaguchi, T.
机构：
[1] Tohoku Univ, Dept Quantum Sci & Energy Engn, Grad Sch Engn, Aoba Ku, Sendai, Miyagi 9808579, Japan
[2] Tohoku Univ, Dept Elect Engn, Grad Sch Engn, Aoba Ku, Sendai, Miyagi 9808579, Japan
[3] Tohoku Univ, Ctr Cyclotron & Radioisotope, Aoba Ku, Sendai, Miyagi 9808579, Japan
[4] Tohoku Univ, Dept Med Sci, Aoba Ku, Grad Sch Med, Sendai, Miyagi 9808579, Japan
[5] Osaka Univ, Dept Nucl Med & Tracer Kinet, Grad Sch Med, Suita, Osaka 5650871, Japan
[6] Kitasato Univ, Sch Vet Med & Anim Sci, Towada, Aomori 0348628, Japan
[7] Sumitomo Heavy Ind Ltd, Ctr Res & Dev, Shinagawa Ku, Tokyo 1418686, Japan
来源：
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT | 2007年 / 576卷 / 2-3期
关键词：
positron emission tomograph; CdTe; semiconductor detector; high resolution; animal PET;
D O I：
10.1016/j.nima.2007.03.018
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
An animal PET scanner using CdTe detectors was developed for the purpose of biomedical study using mice and rats. A spatial resolution of 0.8 mm FWHM within the central 20 mm-diameter of the field of view (FOV) was obtained by small CdTe elements of 1.1 mm x 5.0 mm x 1.0 mm. This spatial resolution is the first achievement of a practical semiconductor animal PET scanner. The determination of the depth of the 7 interaction in the detector was carried out by the use of two detector layers. The FOV is 64 mm in diameter and 26 mm in axis. Fine [F-18]FDG images of the heads of a mouse and a rat, where the cerebral cortex, the gray matter and the corpus striatum could be respectively distinguished, were successfully obtained. This work inspires the dawn of the high resolution semiconductor PET scanner age as the next generation. (C) 2007 Elsevier B.V. All rights reserved.
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页码：435 / 440
页数：6
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