BODIPY-based turn-on fluorescent probes for cysteine and homocysteine

被引：39

作者：

Gao, Jinhua ^{[1
]}

Tao, Yuanfang ^{[1
]}

Wang, Nannan ^{[1
]}

He, Jinling ^{[1
]}

Zhang, Jian ^{[1
]}

Zhao, Weili ^{[1
,2
]}

机构：

[1] Henan Univ, Key Lab Special Funct Mat, Minist Educ, Kaifeng 475004, Peoples R China

[2] Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2018年 / 203卷

基金：

中国国家自然科学基金;

关键词：

BODIPY; Fluorescent probe; Cys/Hcy; Cell imaging; HIGHLY SELECTIVE DETECTION; HYDROGEN-SULFIDE; LIVING CELLS; COLORIMETRIC CHEMOSENSORS; MASS-SPECTROMETRY; EMISSION CHANNELS; RECENT PROGRESS; GLUTATHIONE; THIOLS; DISCRIMINATION;

D O I：

10.1016/j.saa.2018.05.114

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) are interconnected and play essential roles in many biological processes. It is significant importance to detect these thiols for investigating their functions in cells and disease diagnosis. In this work, we have designed and synthesized two novel BODIPY-based turn-on fluorescent probes (BDP-Ph and BDP-R-Ph) carrying 4-methoxythiophenol moiety at mesa position as good leaving group for highly selective detection of Cys and Hcy. Furthermore, the probes have been successfully applied to detect intracellular Cys and Hcy by fluorescent imaging in living cells. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：77 / 84

页数：8

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