Cyanogen Bromide as Dehydrosulfurizing Agent for the Synthesis of Nβ-Fmoc-Amino Alkyl Isonitriles from Nβ-Fmoc-Amino Alkyl Thioformamides

被引：2
作者：
Vishwanatha, T. M. [1 ]
Hemantha, H. P. [1 ]
Sureshbabu, V. V. [1 ]
机构：
[1] Bangalore Univ, Peptide Res Lab, Dept Studies Chem, Bangalore 560001, Karnataka, India
来源：
SYNLETT | 2010年 / 07期
关键词：
N-beta-Fmoc-amino alkyl thioformamides; isonitriles; dehydrosulfurization; cyanogen bromide; 4-COMPONENT REACTION; NATURAL-PRODUCTS; BUILDING-BLOCKS; ISOCYANIDES; DERIVATIVES; ACIDS; ISOTHIOCYANATES; CONDENSATION; CHEMISTRY; MIMETICS;
D O I：
10.1055/s-0029-1219583
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthetically useful N-beta-Fmoc amino alkyl isonitriles are prepared conveniently from N-beta-Fmoc amino alkyl thioformamides via a cyanogen bromide mediated dehydrosulfurization. The reaction is fast, clean, and yields are good.
引用
收藏
页码：1096 / 1100
页数：5
相关论文
共 45 条
  • [41] VANDAAN L, 1991, SYNTHESIS-STUTTGART, P531
  • [42] VANLEUSEN AM, 1972, TETRAHEDRON LETT, V13, P5337
  • [43] Xu P, 2003, SYNTHESIS-STUTTGART, P1171
  • [44] On the preparation of enantiomerically pure isonitriles from amino acid esters and peptides
    Zhu, Jianglong
    Wu, Xiangyang
    Danishefsky, Samuel J.
    [J]. TETRAHEDRON LETTERS, 2009, 50 (05) : 577 - 579
  • [45] HYDROXYLAMINE DERIVATIVES .37. HYDROXYLAMINE IN UGI 4-COMPONENT CONDENSATION
    ZINNER, G
    MODERHACK, D
    KLIEGEL, W
    [J]. CHEMISCHE BERICHTE-RECUEIL, 1969, 102 (08): : 2536 - +
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