MicroRNAs in the tumor endothelium: Novel controls on the angioregulatory switchboard

被引：52
作者：
Heusschen, Roy [2 ]
van Gink, Matthijs [3 ]
Griffioen, Arjan W. [2 ]
Thijssen, Victor L. [1 ]
机构：
[1] Vrije Univ Amsterdam, Med Ctr, Dept Radiotherapy, Angiogenesis Lab, NL-1081 HV Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Med Ctr, Dept Med Oncol, Angiogenesis Lab, NL-1081 HV Amsterdam, Netherlands
[3] Maastricht Univ, Med Ctr, Dept Pathol, Sch Oncol & Dev Biol, Maastricht, Netherlands
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2010年 / 1805卷 / 01期
关键词：
Cancer; Angiogenesis; miRNA; Endothelial cell; NITRIC-OXIDE SYNTHASE; IN-VIVO; VASCULAR INTEGRITY; ANGIOGENIC FACTORS; MOUSE DEVELOPMENT; CANCER; CELLS; EXPRESSION; TARGET; GROWTH;
D O I：
10.1016/j.bbcan.2009.09.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumor angiogenesis facilitates tumor metastasis and allows malignant tissues to grow beyond a diffusion limited size. It is a complex process that requires endothelial cells to execute specific steps during different phases. miRNAs are small non-coding RNAs that act as molecular switches to redirect the expression profile of a cell. Evidence is emerging that miRNAs are important players in endothelial cell biology and tumor angiogenesis. In this review we summarize the available data of miRNA expression in the endothelium. In addition, we describe the current knowledge regarding the function of miRNAs in endothelial cell biology. Finally, we discuss the potential applications of miRNA based treatment strategies in angiostatic cancer therapy. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：87 / 96
页数：10
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