Effect of chronic Sildenafil treatment on the prostate of C57Bl/6 mice

被引：9
|
作者：
dos Santos Gomes, Fabiana Oliveira [1 ,2 ]
Carvalho, Maria da Conceicao [3 ]
Alcantara Saraiva, Karina Lidianne [4 ]
Ribeiro, Edlene Lima [1 ,2 ]
Soares e Silva, Amanda Karolina [1 ,2 ]
Matos Donato, Mariana Aragao [1 ,2 ]
Santos Rocha, Sura Wanessa [1 ,2 ]
Silva, Bruna Santos e [1 ,2 ]
Peixoto, Christina Alves [1 ]
机构：
[1] Fiocruz MS, Inst Aggeu Magalhaes, Lab Ultraestrutura, BR-50670420 Recife, PE, Brazil
[2] Univ Fed Pernambuco UFPE, Recife, PE, Brazil
[3] Ctr Tecnol Estrateg Nordeste CETENE, Lab Microscopia & Microanal, Recife, PE, Brazil
[4] Univ Estadual Paraiba, Dept Biol, Campina Grande, Brazil
来源：
TISSUE & CELL | 2014年 / 46卷 / 06期
关键词：
Sildenafil; Inhibitor of phosphodiesterase-5 (PDE5); Prostate; URINARY-TRACT SYMPTOMS; NITRIC-OXIDE SYNTHASE; PHOSPHODIESTERASE PDE ISOENZYMES; CHRONIC LYMPHOCYTIC-LEUKEMIA; ERECTILE DYSFUNCTION; METABOLIC SYNDROME; STROMAL CELLS; SMOOTH-MUSCLE; IMMUNOHISTOCHEMICAL DISTRIBUTION; PULMONARY-HYPERTENSION;
D O I：
10.1016/j.tice.2014.08.001
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Sildenafil is a potent and selective inhibitor of phosphodiesterase-5 (PDE5) and is considered first-line therapy for erectile dysfunction. Nowadays, Sildenafil is used extensively throughout the world on patients with pulmonary hypertension. However, few studies have evaluated the possible side effects of chronic Sildenafil treatment on the male reproductive system, specifically in the prostate. In the present study, it was demonstrated via morphological and ultrastructural analysis that chronic treatment with Sildenafil induced an enhancement of the glandular activity of the prostate. In addition, mice treated with Sildenafil showed a significant increase in testosterone serum levels. However, no statistically significant differences were observed in nitric oxide serum levels, or in sGC, eNOS, PSA and TGF-beta prostatic expression. In conclusion, the present study suggests that chronic use of Sildenafil does not cause evident prostatic damage, and therefore, can be used pharmacologically to treat a variety of disorders. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：439 / 449
页数：11
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