Murine model of pregnancy-associated Listeria monocytogenes infection

被引:39
作者
Abram, M
Schlüter, D
Vuckovic, D
Wraber, B
Doric, M
Deckert, M
机构
[1] Univ Rijeka, Dept Microbiol, Fac Med, Rijeka 51000, Croatia
[2] Univ Heidelberg, Dept Med Microbiol & Hyg, Mannheim Clin, D-6800 Mannheim, Germany
[3] Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Ljubljana, Slovenia
[4] Univ Cologne, Dept Neuropathol, Cologne, Germany
来源
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2003年 / 35卷 / 03期
关键词
Listeria monocytogenes; pregnancy; cytokine; mouse;
D O I
10.1016/S0928-8244(02)00449-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Listeria monocytogenes has been recognized as a significant pathogen, occurring worldwide, capable of causing animal and human infections. In its most severe form, listeriosis is an invasive disease that affects immunocompromised patients. Additionally, pregnant women represent a high-risk group for L. monocytogenes infection. Abortion, stillbirth or severe neonatal infection can be the serious outcome of such an infection. In an experimental murine model of pregnancy-associated listeriosis we studied the impact of L. monocytogenes on the maternal immune response and pregnancy outcome. In comparison to virgin animals, pregnant mice mounted lower levels of protective cytokines and were inable to eliminate the pathogen. The impaired maternal immune response that has been found both on the systemic and local level, faciliated bacterial multiplication in the liver, placenta and ultimately in the fetal tissues. This resulted in severe necrotizing hemorrhagic hepatitis and Listeria-induced placental necrosis, increasing the incidence of postimplantation loss and poor pregnancy outcome. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:177 / 182
页数:6
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