Transfer of Chirality in the Rhodium-Catalyzed Chemoselective and Regioselective Allylic Alkylation of Hydroxyarenes with Vinyl Aziridines

被引：25

作者：

Lin, Tao-Yan ^{[1
]}

Wu, Hai-Hong ^{[1
]}

Feng, Jian-Jun ^{[1
]}

Zhang, Junliang ^{[1
]}

机构：

[1] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 11期

基金：

中国国家自然科学基金;

关键词：

RING-OPENING REACTIONS; ELECTRON-RICH ARENES; ASYMMETRIC DEAROMATIZATION; ABSOLUTE-CONFIGURATION; BIOLOGICAL EVALUATION; ACTIVATED AZIRIDINES; STEREOGENIC CENTERS; EFFICIENT CATALYST; SYNTHETIC ROUTE; N CYCLIZATION;

D O I：

10.1021/acs.orglett.7b01136

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By taking advantage of chirality-transfer strategy, a chemo- and regioselective allylic alkylation of naphthols and phenols with vinylaziridines provides an atom-economic and efficient method for the synthesis of enantioenriched 2-vinyl-2-arylethylamine derivatives. Use of readily available starting materials, a broad substrate scope, high selectivity, mild reaction conditions, as well as versatile functionalizations of the aromatic ethylamine products make this approach very practical and attractive.

引用

页码：2897 / 2900

页数：4

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