Association between PD-1 and PD-L1 Polymorphisms and the Risk of Cancer: A Meta-Analysis of Case-Control Studies

被引：48
作者：
Hashemi, Mohammad [1 ,2 ]
Karami, Shima [2 ]
Sarabandi, Sahel [2 ]
Moazeni-Roodi, Abdolkarim [3 ]
Malecki, Andrzej [4 ]
Ghavami, Saeid [5 ,6 ]
Wiechec, Emilia [7 ]
机构：
[1] Zahedan Univ Med Sci, Genet Noncommunicable Dis Res Ctr, Zahedan 9816743463, Iran
[2] Zahedan Univ Med Sci, Sch Med, Dept Clin Biochem, Zahedan 9816743175, Iran
[3] Iranshahr Univ Med Sci, Dept Clin Biochem, Iranshahr 9916643535, Iran
[4] Jerzy Kukuczka Acad Phys Educ Katowice, Inst Physiotherapy & Hlth Sci, PL-40065 Katowice, Poland
[5] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Human Anat & Cell Sci, Winnipeg, MB R3E 0J9, Canada
[6] Univ Manitoba, Res Inst Oncol & Hematol, Canc Care Manitoba, Winnipeg, MB R3E 3P5, Canada
[7] Linkoping Univ, Dept Clin & Expt Med, S-58183 Linkoping, Sweden
来源：
CANCERS | 2019年 / 11卷 / 08期
关键词：
apoptosis; PD-1; PD-L1; polymorphism; cancer; meta-analysis; CELL LUNG-CANCER; GENE POLYMORPHISM; IRANIAN PATIENTS; BREAST-CANCER; BINDING-SITE; SUSCEPTIBILITY; PROGNOSIS; C/T; POPULATION; PD-1/PD-L1;
D O I：
10.3390/cancers11081150
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A number of case-control studies regarding the association of the polymorphisms in the programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) genes with the risk of cancer have yielded inconsistent findings. Therefore, we have conducted a comprehensive, updated meta-analysis study to identify the impact of PD-1 and PD-L1 polymorphisms on overall cancer susceptibility. The findings revealed that PD-1 rs2227981 and rs11568821 polymorphisms significantly decreased the overall cancer risk (Odds Ratio (OR) = 0.82, 95% CI = 0.68-0.99, p = 0.04, TT vs. CT+CC; OR = 0.79, 95% CI = 0.67-0.94, p = 0.006, AG vs. GG, and OR = 0.82, 95% CI = 0.70-0.96, p = 0.020, AG+AA vs. GG, respectively), while PD-1 rs7421861 polymorphism significantly increased the risk of developing cancer (OR = 1.16, 95% CI = 1.02-1.33, p = 0.03, CT vs. TT). The PD-L1 rs4143815 variant significantly decreased the risk of cancer in homozygous (OR = 0.62, 95% CI = 0.41-0.94, p = 0.02), dominant (OR = 0.70, 95% CI = 0.50-0.97, p = 0.03), recessive (OR = 0.76, 95% CI = 0.60-0.96, p = 0.02), and allele (OR = 0.78, 95% CI = 0.63-0.96, p = 0.02) genetic models. No significant association between rs2227982, rs36084323, rs10204525, and rs2890658 polymorphisms and overall cancer risk has been found. In conclusions, the results of this meta-analysis have revealed an association between PD-1 rs2227981, rs11568821, rs7421861, as well as PD-L1 rs4143815 polymorphisms and overall cancer susceptibility.
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页数：22
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