Cytogenetic risk stratification may predict allogeneic hematopoietic stem cell transplantation outcomes for chronic myelomonocytic leukemia

被引：10

作者：

Motohashi, Kenji ^{[1
]}

Fujisawa, Shin ^{[1
]}

Doki, Noriko ^{[2
]}

Kobayashi, Takeshi ^{[2
]}

Mori, Takehiko ^{[3
]}

Usuki, Kensuke ^{[4
]}

Tanaka, Masatsugu ^{[5
]}

Fujiwara, Shinichiro ^{[6
]}

Kako, Shinichi ^{[7
]}

Aoyama, Yasuyuki ^{[8
]}

Onoda, Masahiro ^{[9
]}

Yano, Shingo ^{[10
]}

Gotoh, Moritaka ^{[11
]}

Kanamori, Heiwa ^{[5
]}

Takahashi, Satoshi ^{[12
]}

Okamoto, Shinichiro ^{[3
]}

机构：

[1] Yokohama City Univ, Dept Hematol, Med Ctr, Minami Ku, 4-57 Urafunecho, Yokohama, Kanagawa 2320024, Japan

[2] Tokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Div Hematol, Bunkyo Ku, Tokyo, Japan

[3] Keio Univ, Div Hematol, Dept Med, Sch Med, Tokyo, Japan

[4] NTT Med Ctr Tokyo, Dept Hematol, Tokyo, Japan

[5] Kanagawa Canc Ctr, Dept Hematol, Yokohama, Kanagawa, Japan

[6] Jichi Med Univ, Div Hematol, Shimotsuke, Japan

[7] Jichi Med Univ, Saitama Med Ctr, Div Hematol, Saitama, Japan

[8] Tokai Univ, Dept Hematol & Oncol, Sch Med, Isehara, Kanagawa, Japan

[9] Chiba Aoba Municipal Hosp, Dept Internal Med, Chiba, Japan

[10] Jikei Univ, Div Clin Oncol & Hematol, Dept Internal Med, Sch Med, Tokyo, Japan

[11] Tokyo Med Univ Hosp, Dept Hematol, Tokyo, Japan

[12] Univ Tokyo, Inst Med Sci, Dept Hematol & Oncol, Tokyo, Japan

来源：

LEUKEMIA & LYMPHOMA | 2018年 / 59卷 / 06期

关键词：

Cytogenetics; chronic myelomonocytic leukemia; hematopoietic stem transplantation; allogeneic; prognosis; scoring system; MUTATIONS; SCT;

D O I：

10.1080/10428194.2017.1387913

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative treatment for chronic myelomonocytic leukemia (CMML); however, factors predicting allo-HSCT outcomes for CMML have not been well defined. This study assessed whether the existing five scoring systems for CMML prognosis could be applied for predicting allo-HSCT outcomes. We retrospectively evaluated 38 patients who underwent allo-HSCT for CMML from 2000 to 2014. At 3 years, overall survival (OS) and disease-free survival were 34.6 and 24.7%, respectively. According to the risk stratification at the time of transplantation, only the CMML-specific cytogenetic risk scoring system could successfully predict transplantation outcomes. At 3 years, OS was 56.7, 12.5, and 0% (p=.01) in the low, intermediate, and high-risk groups. Our data suggest that the CMML-specific cytogenetic risk stratification at transplant may be useful for identifying patients with CMML who may benefit from HSCT. However, further studies are warranted to confirm this observation.

引用

页码：1332 / 1337

页数：6

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