Fantastic beasts and how to find them-Molecular identification of the mitochondrial ATP-sensitive potassium channel

被引：1

作者：

Davidson, Sean M. ^{[1
]}

Szabadkai, Gyorgy ^{[2
,3
,4
]}

Duchen, Michael R. ^{[2
,3
]}

机构：

[1] UCL, Hatter Cardiovasc Inst, 67 Chenies Mews, London WC1E 6HX, England

[2] UCL, Dept Cell & Dev Biol, Gower St, London WC1E 6BT, England

[3] UCL, UCL Consortium Mitochondrial Res, Gower St, London WC1E 6BT, England

[4] Univ Padua, Dept Biomed Sci, Padua, Italy

来源：

CELL CALCIUM | 2019年 / 84卷

关键词：

Mitochondria; Katp channel; Ischaemia and reperfusion; K+ CHANNEL; COMPONENT;

D O I：

10.1016/j.ceca.2019.102100

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite reported sightings over many years, certain mitochondrial-specific channels have proven to be elusive beasts, evading molecular identification. However, combining modern genetics with a wave of their ion-sensing wand, researchers have managed to capture first the mitochondrial calcium uniporter, and now that semi-mythological beast, the mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel.

引用

页数：2

共 10 条

[1] Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity [J].

Ardehali, H ;

Chen, ZH ;

Ko, Y ;

Mejia-Alvarez, R ;

Marbán, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11880-11885

[2] Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter [J].

Baughman, Joshua M. ;

Perocchi, Fabiana ;

Girgis, Hany S. ;

Plovanich, Molly ;

Belcher-Timme, Casey A. ;

Sancak, Yasemin ;

Bao, X. Robert ;

Strittmatter, Laura ;

Goldberger, Olga ;

Bogorad, Roman L. ;

Koteliansky, Victor ;

Mootha, Vamsi K. .

NATURE, 2011, 476 (7360) :341-U111

[3] A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter [J].

De Stefani, Diego ;

Raffaello, Anna ;

Teardo, Enrico ;

Szabo, Ildiko ;

Rizzuto, Rosario .

NATURE, 2011, 476 (7360) :336-U104

[4] Mapping preconditioning's signaling pathways - An engineering approach [J].

Downey, James M. ;

Krieg, Thomas ;

Cohen, Michael V. .

CONTROL AND REGULATION OF TRANSPORT PHENOMENA IN THE CARDIAC SYSTEM, 2008, 1123 :187-196

[5] Mitochondrial ROMK Channel Is a Molecular Component of MitoKATP [J].

Foster, D. Brian ;

Ho, Alice S. ;

Rucker, Jasma ;

Garlid, Anders O. ;

Chen, Ling ;

Sidor, Agnieszka ;

Garlid, Keith D. ;

O'Rourke, Brian .

CIRCULATION RESEARCH, 2012, 111 (04) :446-454

[6] The mitochondrial KATP channel-Fact or fiction? [J].

Garlid, Keith D. ;

Halestrap, Andrew P. .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2012, 52 (03) :578-583

[7] ATP-SENSITIVE K+ CHANNEL IN THE MITOCHONDRIAL INNER MEMBRANE [J].

INOUE, I ;

NAGASE, H ;

KISHI, K ;

HIGUTI, T .

NATURE, 1991, 352 (6332) :244-247

[8] The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition [J].

Luongo, Timothy S. ;

Lambert, Jonathan P. ;

Yuan, Ancai ;

Zhang, Xueqian ;

Gross, Polina ;

Song, Jianliang ;

Shanmughapriya, Santhanam ;

Gao, Erhe ;

Jain, Mohit ;

Houser, Steven R. ;

Koch, Walter J. ;

Cheung, Joseph Y. ;

Madesh, Muniswamy ;

Elrod, John W. .

CELL REPORTS, 2015, 12 (01) :23-34

[9] Identification of an ATP-sensitive potassium channel in mitochondria [J].

Paggio, Angela ;

Checchetto, Vanessa ;

Campo, Antonio ;

Menabo, Roberta ;

Di Marco, Giulia ;

Di Lisa, Fabio ;

Szabo, Ildiko ;

Rizzuto, Rosario ;

De Stefani, Diego .

NATURE, 2019, 572 (7771) :609-+

[10] ATP-Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles [J].

Tinker, Andrew ;

Aziz, Qadeer ;

Li, Yiwen ;

Specterman, Mark .

COMPREHENSIVE PHYSIOLOGY, 2018, 8 (04) :1463-1511

← 1 →