Daptomycin: pharmacology and clinical use

被引：39
作者：
Kosmidis, Christos [1 ]
Levine, Donald P. [1 ]
机构：
[1] Wayne State Univ, Univ Hlth Ctr, Dept Med, Detroit, MI 48201 USA
来源：
EXPERT OPINION ON PHARMACOTHERAPY | 2010年 / 11卷 / 04期
关键词：
daptomycin; Gram-positive infections; pharmacology; resistance; RESISTANT STAPHYLOCOCCUS-AUREUS; IN-VITRO ACTIVITIES; ACUTE-RENAL-FAILURE; ENTEROCOCCAL BACTEREMIA; COMPLICATED SKIN; REDUCED SUSCEPTIBILITY; BACTERICIDAL ACTIVITY; ANTIMICROBIAL AGENTS; VANCOMYCIN; EXPERIENCE;
D O I：
10.1517/14656561003598893
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Areas covered in this review: Literature from 1986 to present was reviewed for pharmacological, preclinical and clinical studies on daptomycin. What the reader will gain: The pharmacological properties, resistance mechanisms and clinical applications of daptomycin are discussed. Recommendations are offered on the use of this agent for the treatment of resistant Gram-positive infections. Take home message: Daptomycin is a reliable agent for the treatment of Gram-positive infections. It has been shown to be effective in bacteremia and endocarditis, as well as in soft-tissue infections caused by Gram-positive organisms. Its role in the treatment of bone and joint infections is not well-defined. Resistance is currently uncommon in clinical isolates. However, emergence of resistance during therapy is a concern. This may be prevented by use of higher doses.
引用
收藏
页码：615 / 625
页数：11
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