Daptomycin: pharmacology and clinical use

被引：39

作者：

Kosmidis, Christos ^{[1
]}

Levine, Donald P. ^{[1
]}

机构：

[1] Wayne State Univ, Univ Hlth Ctr, Dept Med, Detroit, MI 48201 USA

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2010年 / 11卷 / 04期

关键词：

daptomycin; Gram-positive infections; pharmacology; resistance; RESISTANT STAPHYLOCOCCUS-AUREUS; IN-VITRO ACTIVITIES; ACUTE-RENAL-FAILURE; ENTEROCOCCAL BACTEREMIA; COMPLICATED SKIN; REDUCED SUSCEPTIBILITY; BACTERICIDAL ACTIVITY; ANTIMICROBIAL AGENTS; VANCOMYCIN; EXPERIENCE;

D O I：

10.1517/14656561003598893

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Areas covered in this review: Literature from 1986 to present was reviewed for pharmacological, preclinical and clinical studies on daptomycin. What the reader will gain: The pharmacological properties, resistance mechanisms and clinical applications of daptomycin are discussed. Recommendations are offered on the use of this agent for the treatment of resistant Gram-positive infections. Take home message: Daptomycin is a reliable agent for the treatment of Gram-positive infections. It has been shown to be effective in bacteremia and endocarditis, as well as in soft-tissue infections caused by Gram-positive organisms. Its role in the treatment of bone and joint infections is not well-defined. Resistance is currently uncommon in clinical isolates. However, emergence of resistance during therapy is a concern. This may be prevented by use of higher doses.

引用

页码：615 / 625

页数：11

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