The somatotropic axis and aging: Benefits of endocrine defects

被引：47

作者：

Bartke, Andrzej ^{[1
]}

List, Edward O. ^{[2
,3
]}

Kopchick, John J. ^{[2
,3
]}

机构：

[1] So Illinois Univ, Sch Med, Dept Internal Med, 801 N Rutledge,POB 19628, Springfield, IL 62794 USA

[2] Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 USA

[3] Ohio Univ, Heritage Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA

来源：

GROWTH HORMONE & IGF RESEARCH | 2016年 / 27卷

关键词：

Growth hormone; Growth hormone receptors; Longevity; IGF-1; Liver; Muscle; Adipose tissue; DIET-INDUCED OBESITY; GENE-DISRUPTED MICE; MAMMALIAN LIFE-SPAN; GH-TRANSGENIC MICE; LONG-LIVED MICE; FACTOR-I IGF-1; GROWTH-HORMONE; INSULIN SENSITIVITY; HUMAN LONGEVITY; DWARF MICE;

D O I：

10.1016/j.ghir.2016.02.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reduced somatotropic [growth hormone (GH) and insulin-like growth factor-1 (IGF-1)] action has been associated with delayed and slower aging, reduced risk of frailty, reduced age-related disease and functional decline, and with remarkably extended longevity. Recent studies have added to the evidence that these relationships discovered in laboratory populations of mice apply to other mammalian species. However, the relationship of the somatotropic signaling to human aging is less striking, complex and controversial. In mice, targeted deletion of GH receptors (GHR) in the liver, muscle or adipose tissue affected multiple metabolic parameters but failed to reproduce the effects of global GHR deletion on longevity. Continued search for mechanisms of extended longevity in animals with GH deficiency or resistance focused attention on different pathways of mechanistic target of rapamycin (mTOR), energy metabolism, regulation of local IGF-1 levels and resistance to high-fat diet (HFD). (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：41 / 45

页数：5

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