Impaired Humoral Response in Renal Transplant Recipients to SARS-CoV-2 Vaccination with BNT162b2 (Pfizer-BioNTech)

被引：131

作者：

Korth, Johannes ^{[1
]}

Jahn, Michael ^{[1
]}

Dorsch, Oliver ^{[2
]}

Anastasiou, Olympia Evdoxia ^{[3
]}

Sorge-Haedicke, Burkhard ^{[4
]}

Eisenberger, Ute ^{[1
]}

Gaeckler, Anja ^{[1
]}

Dittmer, Ulf ^{[3
]}

Witzke, Oliver ^{[5
]}

Wilde, Benjamin ^{[1
]}

Dolff, Sebastian ^{[5
]}

Kribben, Andreas ^{[1
]}

机构：

[1] Univ Duisburg Essen, Univ Hosp Essen, Dept Nephrol, Hufelandstr 55, D-45147 Essen, Germany

[2] KfH Kuratorium Dialyse & Nierentransplantat eV, KfH Nierenzentrum Friesener Str 37a, D-96317 Kronach, Germany

[3] Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Virchowstr 179, D-45147 Essen, Germany

[4] KfH Kuratorium Dialyse & Nierentransplantat eV, KfH Nierenzentrum Alfried Krupp Str 43, D-45131 Essen, Germany

[5] Univ Duisburg Essen, Univ Hosp Essen, West German Ctr Infect Dis, Dept Infect Dis, D-45147 Essen, Germany

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 05期

关键词：

SARS-Cov-2; vaccination; renal transplant recipients; renal transplantation; COVID-19;

D O I：

10.3390/v13050756

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has a major impact on transplant recipients, with mortality rates up to 20%. Therefore, the effect of established messenger RNA (mRNA)-based SARS-CoV-2 vaccines have to be evaluated for solid organ transplant patients (SOT) since they are known to have poor responses after vaccination. We investigated the SARS-CoV-2 immune response via SARS-CoV-2 IgG detection in 23 renal transplant recipients after two doses of the mRNA-based SARS-CoV-2 vaccine BNT162b2 following the standard protocol. The antibody response was evaluated once with an anti-SARS-CoV-2 IgG CLIA 15.8 +/- 3.0 days after the second dose. As a control, SARS-CoV-2 IgG was determined in 23 healthcare workers (HCW) and compared to the patient cohort. Only 5 of 23 (22%) renal transplant recipients were tested positive for SARS-CoV-2 IgG antibodies after the second dose of vaccine. In contrast, all 23 (100%) HCWs were tested positive for antibodies after the second dose. Thus, the humoral response of renal transplant recipients after two doses of the mRNA-based vaccine BNT162b2 (Pfizer-BioNTech, Kronach, Germany) is impaired and significantly lower compared to healthy controls (22% vs. 100%; p = 0.0001). Individual vaccination strategies might be beneficial in these vulnerable patients.

引用

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