Immunobiology of Uveal Melanoma: State of the Art and Therapeutic Targets

被引：39

作者：

Basile, Maria Sofia ^{[1
]}

Mazzon, Emanuela ^{[2
]}

Fagone, Paolo ^{[1
]}

Longo, Antonio ^{[3
]}

Russo, Andrea ^{[3
]}

Fallico, Matteo ^{[3
]}

Bonfiglio, Vincenza ^{[3
]}

Nicoletti, Ferdinando ^{[1
]}

Avitabile, Teresio ^{[3
]}

Reibaldi, Michele ^{[3
]}

机构：

[1] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy

[2] IRCCS Ctr Neurolesi Bonino Pulejo, Messina, Italy

[3] Univ Catania, Dept Ophthalmol, Catania, Italy

来源：

FRONTIERS IN ONCOLOGY | 2019年 / 9卷

关键词：

uveal melanoma; inhibitory checkpoints; immunotherapy; immune-escape; immune-privilege; SINUSOIDAL ENDOTHELIAL-CELLS; GROWTH-FACTOR-BETA; MIGRATION INHIBITORY FACTOR; TUMOR-INFILTRATING LYMPHOCYTES; ANTERIOR-CHAMBER; INDOLEAMINE 2,3-DIOXYGENASE; NITRIC-OXIDE; PROGNOSTIC-SIGNIFICANCE; IMMUNE-SYSTEM; FAS LIGAND;

D O I：

10.3389/fonc.2019.01145

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Uveal Melanoma (UM) represents the most common primary intraocular malignant tumor in adults. Although it originates from melanocytes as cutaneous melanoma, it shows significant clinical and biological differences with the latter, including high resistance to immune therapy. Indeed, UM can evade immune surveillance via multiple mechanisms, such as the expression of inhibitory checkpoints (e.g., PD-L1, CD47, CD200) and the production of IDO-1 and soluble FasL, among others. More in-depth understanding of these mechanisms will suggest potential targets for the design of novel and more effective management strategies for UM patients.

引用

页数：14

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