Immunobiology of Uveal Melanoma: State of the Art and Therapeutic Targets

被引：41

作者：

Basile, Maria Sofia ^{[1
]}

Mazzon, Emanuela ^{[2
]}

Fagone, Paolo ^{[1
]}

Longo, Antonio ^{[3
]}

Russo, Andrea ^{[3
]}

Fallico, Matteo ^{[3
]}

Bonfiglio, Vincenza ^{[3
]}

Nicoletti, Ferdinando ^{[1
]}

Avitabile, Teresio ^{[3
]}

Reibaldi, Michele ^{[3
]}

机构：

[1] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy

[2] IRCCS Ctr Neurolesi Bonino Pulejo, Messina, Italy

[3] Univ Catania, Dept Ophthalmol, Catania, Italy

来源：

FRONTIERS IN ONCOLOGY | 2019年 / 9卷

关键词：

uveal melanoma; inhibitory checkpoints; immunotherapy; immune-escape; immune-privilege; SINUSOIDAL ENDOTHELIAL-CELLS; GROWTH-FACTOR-BETA; MIGRATION INHIBITORY FACTOR; TUMOR-INFILTRATING LYMPHOCYTES; ANTERIOR-CHAMBER; INDOLEAMINE 2,3-DIOXYGENASE; NITRIC-OXIDE; PROGNOSTIC-SIGNIFICANCE; IMMUNE-SYSTEM; FAS LIGAND;

D O I：

10.3389/fonc.2019.01145

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Uveal Melanoma (UM) represents the most common primary intraocular malignant tumor in adults. Although it originates from melanocytes as cutaneous melanoma, it shows significant clinical and biological differences with the latter, including high resistance to immune therapy. Indeed, UM can evade immune surveillance via multiple mechanisms, such as the expression of inhibitory checkpoints (e.g., PD-L1, CD47, CD200) and the production of IDO-1 and soluble FasL, among others. More in-depth understanding of these mechanisms will suggest potential targets for the design of novel and more effective management strategies for UM patients.

引用

页数：14

共 140 条

[1] Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease [J].

Achberger, Susan ;

Aldrich, Wayne ;

Tubbs, Raymond ;

Crabb, John W. ;

Singh, Arun D. ;

Triozzi, Pierre L. .

MOLECULAR IMMUNOLOGY, 2014, 58 (02) :182-186

[2] Metastatic uveal melanoma showing durable response to anti-CTLA-4 and anti-PD-1 combination therapy after experiencing progression on anti-PD-1 therapy alone [J].

Afzal, Muhammad Zubair ;

Mabaera, Rodwell ;

Shirai, Keisuke .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2018, 6

[3] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[4] Clinical Outcomes in Metastatic Uveal Melanoma Treated With PD-1 and PD-L1 Antibodies [J].

Algazi, Alain P. ;

Tsai, Katy K. ;

Shoushtari, Alexander N. ;

Munhoz, Rodrigo R. ;

Eroglu, Zeynep ;

Piulats, Josep M. ;

Ott, Patrick A. ;

Johnson, Douglas B. ;

Hwang, Jimmy ;

Daud, Adil I. ;

Sosman, Jeffrey A. ;

Carvajal, Richard D. ;

Chmielowski, Bartosz ;

Postow, Michael A. ;

Weber, Jeffrey S. ;

Sullivan, Ryan J. .

CANCER, 2016, 122 (21) :3344-3353

[5] Uveoscleral outflow - A review [J].

Alm, Albert ;

Nilsson, Siv F. E. .

EXPERIMENTAL EYE RESEARCH, 2009, 88 (04) :760-768

[6] Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node [J].

Alonso, Ruby ;

Flament, Heloise ;

Lemoine, Sebastien ;

Sedlik, Christine ;

Bottasso, Emanuel ;

Peguillet, Isabel ;

Premel, Virginie ;

Denizeau, Jordan ;

Salou, Marion ;

Darbois, Aurelie ;

Nunez, Nicolas Gonzalo ;

Salomon, Benoit ;

Gross, David ;

Piaggio, Eliane ;

Lantz, Olivier .

NATURE COMMUNICATIONS, 2018, 9

[7] Expression of Fas and Fas ligand in uveal melanoma: biological implication and prognostic value [J].

Anastassiou, G ;

Coupland, SE ;

Stang, A ;

Boeloeni, R ;

Schilling, H ;

Bornfeld, N .

JOURNAL OF PATHOLOGY, 2001, 194 (04) :466-472

[8] In-depth proteomic profiling of the uveal melanoma secretome [J].

Angi, Martina ;

Kalirai, Helen ;

Prendergast, Samuel ;

Simpson, Deborah ;

Hammond, Dean E. ;

Madigan, Michele C. ;

Beynon, Robert J. ;

Coupland, Sarah E. .

ONCOTARGET, 2016, 7 (31) :49623-49635

[9]

Apte RS, 1997, INVEST OPHTH VIS SCI, V38, P1277

[10]

Apte RS, 1996, J IMMUNOL, V156, P2667

← 1 2 3 4 5 6 7 8 9 10 →