Transient loss of high-level mupirocin resistance in Staphylococcus aureus due to MupA polymorphism

被引：16

作者：

Driscoll, Daniel G. ^{[1
]}

Young, Casey L. ^{[1
]}

Ochsner, Urs A. ^{[1
]}

机构：

[1] Replidyne Inc, Dept Microbiol, Louisville, CO 80027 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 06期

关键词：

D O I：

10.1128/AAC.00241-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Spontaneous loss of MupA-mediated high-level mupirocin resistance was observed in Staphylococcus aureus, although the isolate gave a PCR-positive test result for mupA. Sequencing of the mupA gene identified a single base-pair deletion that resulted in a frameshift mutation and loss of functional protein. Reversion to the wild-type allele and restoration of high-level resistance occurred with high frequency (>10-6), indicating the transient nature of MupA polymorphism.

引用

页码：2247 / 2248

页数：2

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