Ubiquitylation of ABA Receptors and Protein Phosphatase 2C Coreceptors to Modulate ABA Signaling and Stress Response

被引:19
|
作者
Coego, Alberto [1 ]
Julian, Jose [1 ]
Lozano-Juste, Jorge [1 ]
Pizzio, Gaston A. [1 ]
Alrefaei, Abdulwahed F. [2 ]
Rodriguez, Pedro L. [1 ]
机构
[1] Univ Politecn Valencia, Consejo Super Invest Cient, Inst Biol Mol & Celular Plantas, ES-46022 Valencia, Spain
[2] King Saud Univ, Coll Sci, Zool Dept, Riyadh 11451, Saudi Arabia
关键词
abscisic acid; ABA receptor; clade A PP2C; E3 ubiquitin ligases; PYR; PYL; RCAR; RBR E3 ligase; CRL3; CRL4; RING E3 ligase; PUB E3 ligase; E3; LIGASES; UBIQUITIN; DEGRADATION; TURNOVER; CHANNEL; INTERACTS; MEMBRANE; TARGETS; KINASE; PLAYS;
D O I
10.3390/ijms22137103
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Post-translational modifications play a fundamental role in regulating protein function and stability. In particular, protein ubiquitylation is a multifaceted modification involved in numerous aspects of plant biology. Landmark studies connected the ATP-dependent ubiquitylation of substrates to their degradation by the 26S proteasome; however, nonproteolytic functions of the ubiquitin (Ub) code are also crucial to regulate protein interactions, activity, and localization. Regarding proteolytic functions of Ub, Lys-48-linked branched chains are the most common chain type for proteasomal degradation, whereas promotion of endocytosis and vacuolar degradation is triggered through monoubiquitylation or Lys63-linked chains introduced in integral or peripheral plasma membrane proteins. Hormone signaling relies on regulated protein turnover, and specifically the half-life of ABA signaling components is regulated both through the ubiquitin-26S proteasome system and the endocytic/vacuolar degradation pathway. E3 Ub ligases have been reported that target different ABA signaling core components, i.e., ABA receptors, PP2Cs, SnRK2s, and ABFs/ABI5 transcription factors. In this review, we focused specifically on the ubiquitylation of ABA receptors and PP2C coreceptors, as well as other post-translational modifications of ABA receptors (nitration and phosphorylation) that result in their ubiquitination and degradation.
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页数:11
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