Synthetic study of polyoxypeptin: stereoselective synthesis of the acyl side-chain segment

被引：13
|
作者：
Noguchi, Y [1 ]
Yamada, T [1 ]
Uchiro, H [1 ]
Kobayashi, S [1 ]
机构：
[1] Sci Univ Tokyo, Fac Pharmaceut Sci, Shinjuku Ku, Tokyo 1620826, Japan
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 39期
关键词：
polyoxypeptin; Pd-catalyzed hydrogenolysis; alkenyl oxirane;
D O I：
10.1016/S0040-4039(00)01282-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first synthesis of the acyl side-chain segment of polyoxypeptin, a potent inducer of apoptosis in human pancreatic carcinoma AsPC-1, was accomplished. The key feature of the present synthesis is the stereospecific palladium-catalyzed hydrogenolysis of (Z)-alkenyloxirane to anti-hydroxyalkenoate by an improved method. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7499 / 7502
页数：4
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