Synthetic study of polyoxypeptin: stereoselective synthesis of the acyl side-chain segment

被引：13

作者：

Noguchi, Y ^{[1
]}

Yamada, T ^{[1
]}

Uchiro, H ^{[1
]}

Kobayashi, S ^{[1
]}

机构：

[1] Sci Univ Tokyo, Fac Pharmaceut Sci, Shinjuku Ku, Tokyo 1620826, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 39期

关键词：

polyoxypeptin; Pd-catalyzed hydrogenolysis; alkenyl oxirane;

D O I：

10.1016/S0040-4039(00)01282-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of the acyl side-chain segment of polyoxypeptin, a potent inducer of apoptosis in human pancreatic carcinoma AsPC-1, was accomplished. The key feature of the present synthesis is the stereospecific palladium-catalyzed hydrogenolysis of (Z)-alkenyloxirane to anti-hydroxyalkenoate by an improved method. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7499 / 7502

页数：4

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