Associations between continuous glucose monitoring-derived metrics and HbA1c in patients with type 2 diabetes mellitus

被引：7

作者：

Kurozumi, Akira ^{[1
]}

Okada, Yosuke ^{[1
,2
]}

Mita, Tomoya ^{[3
]}

Wakasugi, Satomi ^{[3
]}

Katakami, Naoto ^{[4
,5
]}

Yoshii, Hidenori ^{[6
]}

Kanda, Kazuko ^{[7
]}

Nishida, Keiko ^{[8
]}

Mine, Shinichiro ^{[9
]}

Tanaka, Yoshiya ^{[1
]}

Gosho, Masahiko ^{[10
]}

Shimomura, Iichiro ^{[4
]}

Watada, Hirotaka ^{[3
]}

机构：

[1] Univ Occupat & Environm Hlth, Dept Internal Med 1, Sch Med, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan

[2] Hosp Univ Occupat & Environm Hlth, Clin Res Ctr, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan

[3] Juntendo Univ, Dept Metab & Endocrinol, Grad Sch Med, 2-1-1 Bunkyo Ku, Tokyo 1138421, Japan

[4] Osaka Univ, Dept Metab Med, Grad Sch Med, 2-2 Yamadaoka, Suita, Osaka, Japan

[5] Osaka Univ, Dept Metab & Atherosclerosis, Grad Sch Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[6] Juntendo Tokyo Koto Geriatr Med Ctr, Dept Med Diabetol & Endocrinol, Koto Ku, Shinsuna 3-3-20, Tokyo 1360075, Japan

[7] Tobata Gen Hosp, Tobata Ku, 1-3-33 Fukuryugi, Kitakyushu, Fukuoka 8040025, Japan

[8] Nishida Keiko Diabet Clin, Yahatanishi Ku, 1-3-26 Mitsusadadai, Kitakyushu, Fukuoka 8070805, Japan

[9] Sasaki Hosp, Yahatanishi Ku, 9-36 Kisshoujirnachi, Kitakyushu, Fukuoka 8071114, Japan

[10] Univ Tsukuba, Fac Med, Dept Biostat, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2022年 / 186卷

关键词：

Continuous glucose monitoring; Type 2 diabetes mellitus; Glucose variability; Hemoglobin A1c; RACIAL-DIFFERENCES; RANGE;

D O I：

10.1016/j.diabres.2022.109836

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: The aim of this study was to define the relationship between time in range (TIR) and hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes mellitus (T2DM). Methods: The glycemic profile of 999 Japanese patients was analyzed with FreeStyle Libre Pro Continuous Glucose Monitoring (FLP-CGM) while they continued their prescribed glucose-lowering medications. FLP-CGM data recorded over 8 consecutive days were analyzed. Results: The regression model for HbA1c on TIR was HbA1c = 9.4966-0.0309 x TIR. The predicted HbA1c level for TIR of 70% was 7.33% and is higher than reports subjecting mostly T1DM. The TIR corresponding to HbA1c 7.0% was 80.64%. The patients with low TIR tended to have long duration of diabetes, used high dose of daily insulin, high body mass index, high HbA1c, liver dysfunction and high triglyceride. Relatively higher percentages of patients of this group used sulfonylureas, glucagon like peptide-1 receptor agonists and insulin. Conclusions: Our data showed predicted HbA1c corresponding to TIR is largely depends on study population, thus is not uniform. Our results provide new insights on the management of T2DM. However, caution should be exercised in extending the HbA1C-TIR relationship using FLP-CGM to any other sensors since there could be a risk of hypoglycemia in doing so.

引用

页数：7

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