No association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and schizophrenia in Asian populations: Evidence from a case-control study and meta-analysis

被引:58
作者
Naoe, Yui [1 ]
Shinkai, Takahiro
Hori, Hiroko
Fukunaka, Yuko
Utsunomiya, Kensuke
Sakata, Shinichi
Matsumoto, Chima
Shimizu, Kazuko
Hwang, Rudi
Ohmori, Osamu
Nakamura, Jun
机构
[1] Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan
[2] Kokura Gamou Hosp, Kokuraminami Ku, Kitakyushu, Fukuoka 8020978, Japan
[3] Mitsubishi Heavy Ind Co Ltd, Hlth Management Dept, Shimonoseki Shipyard & Machinery Works, Shimonoseki, Yamaguchi 7508505, Japan
[4] Kyusyu Rosai Hosp, Dept Psychiat, Kokuraminami Ku, Kitakyushu, Fukuoka 8000296, Japan
[5] Nissan Motor Co Ltd, Nissan Tech Ctr Hlth Promot Ctr, Atsugi, Kanagawa 2430192, Japan
[6] Univ Toronto, Dept Psychiat, Neurogenet Sect, Ctr Addict & Mental Hlth,Clarke Div, Toronto, ON M5T 1R8, Canada
[7] Wakato Hosp, Wakamatsu Ku, Kitakyushu, Fukuoka 8080132, Japan
关键词
schizophrenia; brain-derived neurotrophic factor (BDNF); polymorphism; age of onset; genetic association; meta-analysis; chromosome; 11;
D O I
10.1016/j.neulet.2007.01.006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that plays an important role in the development and maintenance of adult neurons and is important regulator of synaptic plasticity in human brain. It has been reported that there are alterations in BDNF levels in the brains of patients with schizophrenia. It has also been reported that transneuronal transfer of BDNF is dependent on neuronal activity, suggesting that BDNF plays an important role in neurotransmission. A single nucleotide polymorphism (SNP) in the BDNF gene that causes a valine to methionine substitution at codon 66 (Val66Met) has been demonstrated to affect human memory and hippocampal function. A possible positive association between the BDNF Val66Met polymorphism and schizophrenia has also been shown in Scottish and Spanish populations. Furthermore, the BDNF Va166Met polymorphism has been implicated in the age of onset of schizophrenia. In the present study, we attempted to replicate these findings in a Japanese case-control sample (211 patients with schizophrenia and 205 controls). We did not find an association between the BDNF Val66Met polymorphism and schizophrenia. An association between the Va166Met polymorphism and age of onset was not observed either. Furthermore, a meta-analysis including the present and previous Asian studies comparing 2059 patients with schizophrenia and 2765 controls also revealed no significant association between the BDNF Va166Met polymorphism and schizophrenia. Our results do not support a significant role for the BDNF Val66Met polymorphism in the development of schizophrenia in Asian populations. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:108 / 112
页数:5
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