USING A MOLECULAR SENSOR ARRAY WITH COLORIMETRIC DETECTION TO IDENTIFY ACTIVE INGREDIENTS IN DRUG FORMULATIONS

被引：2

作者：

Chaplenko, A. A. ^{[1
]}

Monogarova, O. V. ^{[1
]}

Oskolok, K. V. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, 1-3 Leninskie Gory, Moscow 119991, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2019年 / 53卷 / 04期

关键词：

molecular sensor; digital colorimetry; active ingredient; medicine; drug substance; QUALITY-CONTROL; COLOR; ASSAY;

D O I：

10.1007/s11094-019-02004-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A method for multiplex digital colorimetric qualitative analysis of nonsteroidal anti-inflammatory drugs (meloxicam, acetylsalicylic acid and its metabolites, paracetamol), beta-adrenoblockers (carvedilol), secretolytics (bromhexine), fluoroquinolones (ofloxacin), metabolic stimulants (meldonium dihydrate), etc., was developed. The molecular chip operating efficiency was confirmed by verifying the authenticity of >40 medicinal substances. The proposed universal approach was new in principle and could be used for pharmaceutical quality control.

引用

页码：347 / 352

页数：6

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