The yeast CLC chloride channel functions in cation homeostasis

被引：146

作者：

Gaxiola, RA

Yuan, DS

Klausner, RD

Fink, GR

机构：

[1] MIT, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[3] NICHHD, Cell Biol & Metab Branch, Bethesda, MD 20892 USA

[4] NCI, Off Director, NIH, Bethesda, MD 20892 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 07期

关键词：

D O I：

10.1073/pnas.95.7.4046

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A defect in the yeast GEF1 gene, a CLC chloride channel homolog leads to an iron requirement and cation sensitivity, The iron requirement is due to a failure to load Cu2+ onto a component of the iron uptake system, Fet3, This profess, which requires both Gef1 and the Menkes disease Cu2+-ATPase yeast homolog Ccc2, occurs in late-or post-Golgi vesicles, where Gef1 and Ccc2 are localized, The defects of gef1 mutants can be suppressed by the introduction of Torpedo marmorata CLC-0 or arabidopsis thaliana CLC-c and -d chloride channel genes, The functions of Gef1 in cation homeostasis provide clues to the understanding of diseases caused by chloride channel mutations in humans and cation toxicity in plants.

引用

页码：4046 / 4050

页数：5

共 29 条

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