Amperometric In Vitro Monitoring of Penetration through Skin Membrane

被引：5

作者：

Gari, Hala ^{[1
]}

Rembiesa, Jadwiga ^{[1
]}

Masilionis, Ignas ^{[1
]}

Vreva, Naida ^{[1
]}

Svensson, Birgitta ^{[2
]}

Sund, Torbjorn ^{[2
]}

Hansson, Henri ^{[3
]}

Moren, Anna Karin ^{[3
]}

Sjoo, Malin ^{[4
]}

Wahlgren, Marie ^{[5
]}

Engblom, Johan ^{[1
]}

Ruzgas, Tautgirdas ^{[1
]}

机构：

[1] Malmo Univ, Fac Hlth & Soc, Dept Biomed Sci, S-20506 Malmo, Sweden

[2] Bioglan AB, S-20213 Malmo, Sweden

[3] Galenica AB, S-20512 Malmo, Sweden

[4] Speximo AB, S-22381 Lund, Sweden

[5] Lund Univ, Ctr Chem, LTH, Div Food Technol, S-22100 Lund, Sweden

来源：

ELECTROANALYSIS | 2015年 / 27卷 / 01期

基金：

瑞典研究理事会;

关键词：

Penetration; Transdermal delivery; Amperometry; Quercetin; Hydrogen peroxide; Ascorbic acid; Skin membrane; TRANSDERMAL DRUG-DELIVERY; REAL-TIME; OXIDATIVE STRESS; HEAT-SEPARATION; ASCORBIC-ACID; DAMAGED SKIN; ELECTRODES; QUERCETIN; PERMEATION; ABSORPTION;

D O I：

10.1002/elan.201400426

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The aim of this study was to demonstrate that penetration of quercetin, hydrogen peroxide and ascorbic acid through skin membranes can be monitored amperometrically. Skin membrane was fixed on the top of chemically modified electrodes and penetration of the appropriate compound was registered as electrode current. The methodology allows the study of penetration from solution as well as from pharmaceutical creams. From real-time measurements of electrode current, fluxes and diffusion coefficients of mentioned compounds in skin membranes have been estimated.

引用

页码：111 / 117

页数：7

共 31 条

[1] Real-time amperometric analysis of reactive oxygen and nitrogen species released by single immunostimulated macrophages
Amatore, Christian
Arbault, Stephane
Bouton, Cecile
Drapier, Jean-Claude
Ghandour, Hala
Koh, Alaric C. W.
[J]. CHEMBIOCHEM, 2008, 9 (09) : 1472 - 1480
[2] MONITORING AN OXIDATIVE STRESS MECHANISM AT A SINGLE HUMAN FIBROBLAST
ARBAULT, S
PANTANO, P
JANKOWSKI, JA
VUILLAUME, M
AMATORE, C
[J]. ANALYTICAL CHEMISTRY, 1995, 67 (19) : 3382 - 3390
[3] Oxidative stress in cancer prone xeroderma pigmentosum fibroblasts. Real-time and single cell monitoring of superoxide and nitric oxide production with microelectrodes
Arbault, S
Sojic, N
Bruce, D
Amatore, C
Sarasin, A
Vuillaume, M
[J]. CARCINOGENESIS, 2004, 25 (04) : 509 - 515
[4] Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring
Bandodkar, Amay J.
Molinnus, Denise
Mirza, Omar
Guinovart, Tomas
Windmiller, Joshua R.
Valdes-Ramirez, Gabriela
Andrade, Francisco J.
Schoening, Michael J.
Wang, Joseph
[J]. BIOSENSORS & BIOELECTRONICS, 2014, 54 : 603 - 609
[5] Tattoo-based potentiometric ion-selective sensors for epidermal pH monitoring
Bandodkar, Amay J.
Hung, Vinci W. S.
Jia, Wenzhao
Valdes-Ramirez, Gabriela
Windmiller, Joshua R.
Martinez, Alexandra G.
Ramirez, Julian
Chan, Garrett
Kerman, Kagan
Wang, Joseph
[J]. ANALYST, 2013, 138 (01) : 123 - 128
[6] Skin Membrane Electrical Impedance Properties under the Influence of a Varying Water Gradient
Bjorklund, Sebastian
Ruzgas, Tautgirdas
Nowacka, Agnieszka
Dahi, Ihab
Topgaard, Daniel
Sparr, Emma
Engblom, Johan
[J]. BIOPHYSICAL JOURNAL, 2013, 104 (12) : 2639 - 2650
[7] In vitro evaluation of quercetin cutaneous absorption from topical formulations and its functional stability by antioxidant activity
Casagrande, Rubia
Georgetti, Sandra R.
Verri, Waldiceu A., Jr.
Borin, Maria F.
Lopez, Renata F. V.
Fonseca, Maria J. V.
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 328 (02) : 183 - 190
[8] Sensor and biosensor based on Prussian Blue modified gold and platinum screen printed electrodes
de Mattos, IL
Gorton, L
Ruzgas, T
[J]. BIOSENSORS & BIOELECTRONICS, 2003, 18 (2-3) : 193 - 200
[9] INVITRO SKIN PERMEATION TECHNIQUES
FRIEND, DR
[J]. JOURNAL OF CONTROLLED RELEASE, 1992, 18 (03) : 235 - 248
[10] Microneedle Electrodes Toward an Amperometric GlucoseSensing Smart Patch
Invernale, Michael A.
Tang, Benjamin C.
York, Royce L.
Le, Long
Hou, David Yupeng
Anderson, Daniel G.
[J]. ADVANCED HEALTHCARE MATERIALS, 2014, 3 (03) : 338 - 342

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